Upregulated Fibulin-1 Increased Endometrial Stromal Cell Viability and Migration by Repressing EFEMP1-Dependent Ferroptosis in Endometriosis

Figure 1

FBLN1 expression was upregulated in eutopic and ectopic endometrial tissues with EMS. (a) The datasets of GSE58178, GSE23339, and GSE25628 were downloaded from the GEO database, and the differentially expressed genes were identified using Venn diagram analysis. (b) qPCR analysis of 11 common dysregulated genes (FBLN1, PDLIM3, MYH11, AEBP1, EFEMP1, CXCL12, TCEAL2, RARRES2, PDGFRL, CXADR, and MME) in ectopic endometrial tissues (), paired eutopic endometrial tissues (), and normal endometrial tissues (). (c) Western blot analysis of FBLN1 protein expression in ectopic endometrial tissues (), paired eutopic endometrial tissues (), and normal endometrial tissues (). (d) IHC analysis of FBLN1 level in ectopic endometrial tissues (), paired eutopic endometrial tissues (), and normal endometrial tissues (). The representative IHC image was shown in the left panel, and FBLN1 IHC score was shown in the right panel. , , and .

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