TY - JOUR A2 - Kabir, Yearul AU - Siddiqui, Arif Jamal AU - Jahan, Sadaf AU - Singh, Ritu AU - Saxena, Juhi AU - Ashraf, Syed Amir AU - Khan, Andleeb AU - Choudhary, Ranjay Kumar AU - Balakrishnan, Santhanaraj AU - Badraoui, Riadh AU - Bardakci, Fevzi AU - Adnan, Mohd PY - 2022 DA - 2022/03/02 TI - Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention SP - 5425485 VL - 2022 AB - Cancer is one of the primary causes of mortality globally, and the discovery of new anticancer drugs is the most important need in recent times. Natural products have been recognized as effective in fight against various diseases including cancer for over 50 years. Plants and microbes are the primary and potential sources of natural compounds to fight against cancer. Moreover, researches in the field of plant-based natural compounds have moved towards advanced and molecular level understandings from the last few decades, leading to the development of potent anticancer agents. Also, plants have been accepted as abundant and prosperous sources for the development of novel therapeutic agents for the management and prevention of different cancer types. The high toxicity of some cancer chemotherapy drugs, as well as their unfavorable side effects and drugs resistance, drives up the demand for natural compounds as new anticancer drugs. In this detailed evidence-based mechanistic review, facts and information about various medicinal plants, their bioactive compounds with their potent anticancer activities against different cancers have been gathered, with further approach to represent the molecular mechanism behind the anticancer activity of these plants. This review will be beneficial for investigators/scientists globally involved in the development of natural, safe, effective, and economical therapeutic agents/drugs against various cancers. This might be an important contribution in the field of drug discovery, where drugs can be used alone or in combination to increase the efficacy of newly synthesized drugs. SN - 2314-6133 UR - https://doi.org/10.1155/2022/5425485 DO - 10.1155/2022/5425485 JF - BioMed Research International PB - Hindawi KW - ER -