Identification and Verification of Tumor Immune Microenvironment-Related Prognostic Genes in Kidney Renal Clear Cell Carcinoma

Figure 4

Construction and evaluation of the 12-gene risk model in KIRC. (a) The LASSO coefficient profiles of the 54 immune-related prognostic genes. (b) Partial likelihood deviance for LASSO coefficient profiles and optimal lambda selection in the LASSO model. (c, e) Kaplan-Meier analysis of TCGA KIRC discovery cohort and test cohort. (d, f) Time-dependent ROC curves displayed the predictive value of our prognostic model in TCGA discovery and test cohorts. (g) Kaplan-Meier analysis of ICGC external validation cohort. (h) Time-dependent ROC curves displayed the predictive value of our model in ICGC external validation dataset.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)