Research Article
[Retracted] Identification of Molecular Biomarkers and Key Pathways for Esophageal Carcinoma (EsC): A Bioinformatics Approach
Table 3
Gene Ontology analysis of upregulated DEGs using DAVID functional tools.
| Category | GO ID | GO term | Count | % | value |
| BP | GO:0045892 | Negative regulation of transcription, DNA-templated | 22 | 0.035989 | 0.001478 | BP | GO:0046513 | Ceramide biosynthetic process | 5 | 0.008179 | 0.001541 | BP | GO:0016567 | Protein ubiquitination | 17 | 0.02781 | 0.00305 | BP | GO:0051726 | Regulation of cell cycle | 9 | 0.014723 | 0.003954 | BP | GO:0048013 | Ephrin receptor signaling pathway | 7 | 0.011451 | 0.008317 | BP | GO:0016477 | Cell migration | 10 | 0.016359 | 0.008953 | BP | GO:0000045 | Autophagosome assembly | 5 | 0.008179 | 0.009555 | BP | GO:0045893 | Positive regulation of transcription, DNA-templated | 20 | 0.032717 | 0.009702 | BP | GO:0055007 | Cardiac muscle cell differentiation | 4 | 0.006543 | 0.017191 | BP | GO:0051865 | Protein autoubiquitination | 5 | 0.008179 | 0.018845 | CC | GO:0005789 | Endoplasmic reticulum membrane | 37 | 0.060527 | 1.84E-05 | CC | GO:0005654 | Nucleoplasm | 83 | 0.135776 | 8.75E-05 | CC | GO:0005634 | Nucleus | 136 | 0.222477 | 7.26E-04 | CC | GO:0005802 | Trans-Golgi network | 10 | 0.016359 | 0.001509 | CC | GO:0031965 | Nuclear membrane | 13 | 0.021266 | 0.002026 | CC | GO:0005622 | Intracellular | 39 | 0.063798 | 0.013664 | CC | GO:0005737 | Cytoplasm | 123 | 0.201211 | 0.015049 | CC | GO:0005829 | Cytosol | 80 | 0.130869 | 0.036397 | CC | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | 3 | 0.004908 | 0.038709 | CC | GO:0000139 | Golgi membrane | 19 | 0.031081 | 0.046953 | MF | GO:0005515 | Protein binding | 237 | 0.387698 | 1.25E-08 | MF | GO:0003677 | DNA binding | 56 | 0.091608 | 5.22E-04 | MF | GO:0003684 | Damaged DNA binding | 7 | 0.011451 | 0.002026 | MF | GO:0004842 | Ubiquitin-protein transferase activity | 16 | 0.026174 | 0.004151 | MF | GO:0061630 | Ubiquitin protein ligase activity | 11 | 0.017994 | 0.00625 | MF | GO:0005070 | SH3/SH2 adaptor activity | 6 | 0.009815 | 0.006276 | MF | GO:0008565 | Protein transporter activity | 6 | 0.009815 | 0.017551 | MF | GO:0017137 | Rab GTPase binding | 8 | 0.013087 | 0.022939 | MF | GO:0003676 | Nucleic acid binding | 31 | 0.050712 | 0.02606 | MF | GO:0032794 | GTPase activating protein binding | 3 | 0.004908 | 0.03379 |
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GO: Gene Ontology; BP: biological process; CC: cellular component; MF: molecular function. |