Association of Interleukin-1 Beta and Interleukin-1 Receptor Antagonist Gene Polymorphisms and Plasma Levels with Diabetic Nephropathy

Table 3

The genotype and allele frequencies of IL-1β (-511C/T), IL-1β (+3953C/T), and IL-1Ra (+8006C/T) in the DN and HC groups (% of total).

Genotype or allele	DN	HC			OR (95% CI)
	()	()
IL-1β (-511)
TT	46 (75.4)	22 (45.8)	10.014	0.01	3.66 (0.968~13.827)
TC	11 (18.0)	19 (39.6)			1.01 (0.683~1.473)
CC	4 (6.6)	7 (14.6)			1.00
T	103 (84.4)	63 (65.6)	10.465	<0.01	2.84 (1.489~5.416)
C	19 (15.6)	33 (34.4)			1.00
IL-1β (+3953)
TT	16 (26.2)	16 (33.3)	2.510	0.29	0.95 (0.378~2.401)
TC	24 (39.3)	12 (25.0)			1.91 (0.755~4.802)
CC	21 (34.4)	20 (41.7)			1.00
T	56 (45.9)	44 (45.8)	0.000	0.99	1.00 (0.586~1.715)
C	66 (54.1)	52 (54.2)			1.00
IL-1Ra (+8006)
TT	1 (1.6)	1 (2.1)	0.318	1.00	0.78 (0.047~12.869)
TC	10 (16.4)	8 (16.7)			0.98 (0.352~2.703)
CC	50 (82.0)	39 (81.2)			1.00
T	12 (9.8)	10 (10.4)	0.020	0.89	0.94 (0.387~2.274)
C	110 (90.2)	86 (89.6)			1.00

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