Association of lncRNA PVT1 Gene Polymorphisms with the Risk of Essential Hypertension in Chinese Population

Table 5

Association between lncRNA PVT1 polymorphisms and EH risk in China.

Models	Genotypes	Control, (%)	EH, (%)	Unadjusted OR (95% CI)	value	Adjusted OR (95% CI)	Adjusted value
rs10956390
Additive	CC	108 (24.6)	192 (36.6)	1.00 (reference)		1.00 (reference)
	CT	220 (50.1)	233 (44.5)	0.596 (0.442-0.804)	0.001	0.488 (0.326-0.729)	<0.001
	TT	111 (25.3)	99 (18.9)	0.502 (0.350-0.718)	<0.001	0.460 (0.286-0.740)	0.001
Dominant	CC	108 (24.6)	192 (36.6)	1.00 (reference)		1.00 (reference)
	CT/TT	331 (75.4)	332 (63.4)	0.564 (0.426-0.747)	<0.001	0.478 (0.328-0.698)	<0.001
Recessive	CC/CT	328 (74.7)	425 (81.1)	1.00 (reference)		1.00 (reference)
	TT	111 (25.3)	99 (18.9)	0.688 (0.506-0.936)	0.017	0.721 (0.483-1.077)	0.110
rs80177647
Additive	TT	377 (85.9)	395 (75.4)	1.00 (reference)		1.00 (reference)
	TA	57 (13.0)	119 (22.7)	1.993 (1.410-2.816)	<0.001	1.768 (1.144-2.731)	0.010
	AA	5 (1.1)	10 (1.9)	1.909 (0.646-5.636)	0.242	1.170 (0.250-5.40)	0.842
Dominant	TT	377 (85.9)	395 (75.4)	1.00 (reference)		1.00 (reference)
	TA/AA	62 (14.1)	129 (24.6)	1.986 (1.422-2.774)	<0.001	1.723 (1.128-2.631)	0.012
Recessive	TT/TA	434 (98.9)	514 (98.1)	1.00 (reference)		1.00 (reference)
	AA	5 (1.1)	10 (1.9)	1.689 (0.573-4.978)	0.342	1.045 (0.221-4.927)	0.956

OR: odd ratio; CI: confidence interval; EH: essential hypertension. Adjusted for age, gender, BMI, smoking history, FBG, and dyslipidemia.