Ease to Challenges in Achieving Successful Synthesized Schiff Base, Chirality, and Application as Antibacterial Agent

Table 5

Fourteen Schiff bases synthesized from aromatic aldehydes using green and conventional methods [21].

Compound	R1	R2	R3	R4	Reaction time		Yields (%)
					Green	Conv.	Green	Conv.
1a	OH	H	H	H	8 min	2 h	95	65
1b	H	H	OH	H	5 min	4 h	98	54
1c	OH	H	H	H	10 min	2 h	96	66
1d	H	H	H	H	20 min	4 h	96	71
1e	H	H	Cl	H	22 min	4 h	97	90
1f	OH	H	H	Cl	10 min	2 h	95	74
1 g	OH	H	H	Br	8 min	1 h	94	52
2a	OH	H	H	H	8 min	4 h	97	48
2b	H	OH	H	H	5 min	5 h	98	55
2c	H	H	OH	H	10 min	1 h	96	62
2d	H	H	H	H	20 min	3 h	95	64
2e	H	H	Cl	H	22 min	2 h	96	55
2f	OH	H	H	Cl	10 min	1 h	95	58
2 g	OH	H	H	H	8 min	2 h	97	52

Note: Conv.: conventional method.