Research Article

Synthesis, Anticancer, and Antimicrobial Evaluation of Integerrimide-A

Table 4

Results of cytotoxic effects of cyclopeptide IG-A.

CompoundConc. (μg/mL)HCT116 (human colon carcinoma)B16F10 (melanoma cells)
Live cells countedNo. of dead cells% growth inhibitionCTC50 (μM)Live cells countedNo. of dead cells% growth inhibitionCTC50 (μM)

Control (saline)12040.00040.000
6040.00040.000
3040.00040.000
1540.00040.000
7.540.00040.000

IG-A (8)12077.6468.62
60
30
15
7.5

Doxorubicin (standard)120048.64043.24
6000
30
15
7.5