Research Article
Synthesis, Anticancer, and Antimicrobial Evaluation of Integerrimide-A
Table 4
Results of cytotoxic effects of cyclopeptide IG-A.
| Compound | Conc. (μg/mL) | HCT116 (human colon carcinoma) | B16F10 (melanoma cells) | Live cells counted | No. of dead cells | % growth inhibition | CTC50 (μM) | Live cells counted | No. of dead cells | % growth inhibition | CTC50 (μM) |
| Control (saline) | 120 | 40.0 | 0 | 0 | — | 40.0 | 0 | 0 | — | 60 | 40.0 | 0 | 0 | 40.0 | 0 | 0 | 30 | 40.0 | 0 | 0 | 40.0 | 0 | 0 | 15 | 40.0 | 0 | 0 | 40.0 | 0 | 0 | 7.5 | 40.0 | 0 | 0 | 40.0 | 0 | 0 |
| IG-A (8) | 120 | | | | 77.64 | | | | 68.62 | 60 | | | | | | | 30 | | | | | | | 15 | | | | | | | 7.5 | | | | | | |
| Doxorubicin (standard) | 120 | 0 | | | 48.64 | 0 | | | 43.24 | 60 | 0 | | | 0 | | | 30 | | | | | | | 15 | | | | | | | 7.5 | | | | | | |
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