Investigation on the Mechanisms of <i>Zanthoxylum bungeanum</i> for Treating Diabetes Mellitus Based on Network Pharmacology, Molecular Docking, and Experiment Verification

<div>Effect of ZBE on expressions of AKT, P-AKT, FOXO1, P-FOXO1, and JNK proteins in HepG2 cells. 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602Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.365,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg> and <sup>##</sup><svg height="9.2729pt" id="M24" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 44.8393 9.2729" width="44.8393pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 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499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. the model group.</div>

BioMed Research International

fig13

Figure 13

Figure 13: Investigation on the Mechanisms of <i>Zanthoxylum bungeanum</i> for Treating Diabetes Mellitus Based on Network Pharmacology, Molecular Docking, and Experiment Verification 

Figure 13 | Investigation on the Mechanisms of Zanthoxylum bungeanum for Treating Diabetes Mellitus Based on Network Pharmacology, Molecular Docking, and Experiment Verification 