BioMed Research International

Cell Biology of Pathogenic Protozoa and Their Interaction with Host Cells


Publishing date
25 Apr 2014
Status
Published
Submission deadline
06 Dec 2013

1Universidade Santa Ursula, Rio de Janeiro, RJ, Brazil

2University of California, San Francisco Pathology Center for Discovery and Innovation in Parasite Diseases (CDIPD), California Institute for Quantitative Biosciences (QB3), San Francisco, CA, USA

3Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, National University of Singapore, Singapore

4Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil


Cell Biology of Pathogenic Protozoa and Their Interaction with Host Cells

Description

Pathogenic protozoa comprise a large number of eukaryotic microorganisms which are the causative agent of important parasitic diseases. Some affect human and are of high medical relevance as malaria, toxoplasmosis, leishmaniasis, the Chagas disease, sleepiness disease, amebiasis, giardiasis, and trichomoniasis. Others affect animals of large economic interest causing diseases as eimeriosis, bebesiosis, theileriosis, and so on. In addition to their pathogenic importance, these organisms constitute fascinating cell biology models for, at least, two important reasons. First, some of them present unique structures and organelles as glycosomes, kinetoplast, paraflagellar rod, hydrogenosomes, mitosomes, apicoplast, axostyle, costa, and so on. Second, they are able to attach to cells from their host and trigger a process of endocytosis leading to parasite internalization and survival within mammalian cells where part of their life cycle takes place.

The main focus of this special issue will be on the new morphological, biochemical, and molecular information which contribute to a better understanding of the biology of these organisms as well as of their interaction with host cells. It will become an international forum for researchers to summarize the most recent advances and ideas in the field. Special emphasis will be given to studies aiming for the identification of new potential drug targets aiming to contribute to the design of better chemotherapeutic alternatives to treat diseases caused by pathogenic protozoa. Potential topics include, but are not limited to:

  • Morphological studies especially those using modern microscopy techniques
  • Isolation and morphological and biochemical characterization of cell structures and organelles
  • Identification, characterization, and localization of new molecules involved in key regulatory functions
  • Cell death
  • Cell differentiation
  • Protozoa-host cell recognition
  • Host cell invasion by protozoa
  • Intracellular survival of protozoa
  • Protozoa egress from the host cell
  • Cytoskeletal functions (actin and microtubules)

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/cell.biology/cbpp/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 143418
  • - Editorial

Cell Biology of Pathogenic Protozoa and Their Interaction with Host Cells

Marlene Benchimol | Juan C. Engel | ... | Wanderley de Souza
  • Special Issue
  • - Volume 2014
  • - Article ID 565291
  • - Review Article

An Historical Perspective on How Advances in Microscopic Imaging Contributed to Understanding the Leishmania Spp. and Trypanosoma cruzi Host-Parasite Relationship

P. T. V. Florentino | F. Real | ... | R. A. Mortara
  • Special Issue
  • - Volume 2014
  • - Article ID 869401
  • - Research Article

Role of Calcium Signaling in the Transcriptional Regulation of the Apicoplast Genome of Plasmodium falciparum

Sabna Cheemadan | Ramya Ramadoss | Zbynek Bozdech
  • Special Issue
  • - Volume 2014
  • - Article ID 127453
  • - Research Article

Entamoeba histolytica and E. dispar Calreticulin: Inhibition of Classical Complement Pathway and Differences in the Level of Expression in Amoebic Liver Abscess

Cecilia Ximénez | Enrique González | ... | René Cerritos
  • Special Issue
  • - Volume 2014
  • - Article ID 324230
  • - Review Article

Peroxynitrite and Peroxiredoxin in the Pathogenesis of Experimental Amebic Liver Abscess

Judith Pacheco-Yepez | Rosa Adriana Jarillo-Luna | ... | Rafael Campos-Rodriguez
  • Special Issue
  • - Volume 2014
  • - Article ID 209163
  • - Research Article

Strain-Dependent Induction of Human Enterocyte Apoptosis by Blastocystis Disrupts Epithelial Barrier and ZO-1 Organization in a Caspase 3- and 9-Dependent Manner

Zhaona Wu | Haris Mirza | ... | Kevin S. W. Tan
  • Special Issue
  • - Volume 2014
  • - Article ID 439501
  • - Research Article

Early Trypanosoma cruzi Infection Reprograms Human Epithelial Cells

María Laura Chiribao | Gabriela Libisch | ... | Carlos Robello
  • Special Issue
  • - Volume 2014
  • - Article ID 305239
  • - Research Article

Gene Expression Changes Induced by Trypanosoma cruzi Shed Microvesicles in Mammalian Host Cells: Relevance of tRNA-Derived Halves

Maria R. Garcia-Silva | Florencia Cabrera-Cabrera | ... | Alfonso Cayota
  • Special Issue
  • - Volume 2014
  • - Article ID 614014
  • - Review Article

The Double-Edged Sword in Pathogenic Trypanosomatids: The Pivotal Role of Mitochondria in Oxidative Stress and Bioenergetics

Rubem Figueiredo Sadok Menna-Barreto | Solange Lisboa de Castro
  • Special Issue
  • - Volume 2014
  • - Article ID 893272
  • - Research Article

Tracking the Biogenesis and Inheritance of Subpellicular Microtubule in Trypanosoma brucei with Inducible YFP-α-Tubulin

Omar Sheriff | Li-Fern Lim | Cynthia Y. He
BioMed Research International
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Acceptance rate31%
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CiteScore3.600
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