BioMed Research International

Control of Autophagy in Cancer


Status
Published

1Warsaw University of Life Sciences (SGGW), Warszawa, Poland

2Università degli Studi di Parma, Parma, Italy

3Gustave Roussy Cancer Campus, Villejuif, France

4Mossakowski Medical Research Centre PAS, Warsaw, Poland


Control of Autophagy in Cancer

Description

Autophagy is a widely known adaptive mechanism observed in insufficiently nourished cells. Cancer cells in turn are featured by excessive proliferation and migration leading to higher demands for energy and nutrients. Achieving control of autophagy could become a novel therapeutic approach to limit growth and number of neoplastic cells, because inhibition of autophagy often causes tumor cell death by apoptosis. Calcium-permeable ion channels seem to be involved in autophagy of cancer cells. Modulation of calcium homeostasis evokes autophagy-like process in neoplastic cells. Other substances of natural origin were also observed to induce autophagy in cancer cells. This proposal is intended to attract investigators focusing their attention on substances specifically triggering cell death of cancer cells, without affecting healthy controls, even though the precise signaling network of their action remains obscure.

Methods and biomarkers for monitoring autophagy and cell death today represent one of the most active areas in current research on tumor biology. Cancer treatment often requires adjuvant therapies, crucial for followup and final outcome. Despite being well developed, most cancer therapies still require molecular investigations for further advances in this field. A better understanding of the fundamental biological mechanisms involved in cancer onset, progression, and pathogenesis is required, as well as further advances in genomic, transcriptomic, proteomic, and metabolomic research.

This special issue will welcome papers describing the state of the art, advantages and disadvantages, current limitations, and future perspectives of autophagy in the fight against cancer. Particular attention will be given to papers demonstrating specific effects on cancer cells of selected substances controlling autophagy. Of special interest are papers dealing with evidence for the clinical use substances known to markedly limit growth of tumors.

We invite investigators to contribute original research papers and reviews on autophagy and cell death in cancer. Potential topics include, but are not limited to:

  • Methodological approaches
  • Imaging techniques
  • Calcium-permeable ion channels controlling autophagy
  • Energy metabolism/metabolomic
  • Impact of autophagy on carcinogenesis and cancer progression
  • Autophagy and immune escape
  • Substances controlling autophagy in cancer cells

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/oncology/cac/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 698740
  • - Editorial

Control of Autophagy in Cancer

Arkadiusz Orzechowski | Saverio Bettuzzi | ... | Beata Pająk
  • Special Issue
  • - Volume 2015
  • - Article ID 121826
  • - Review Article

Roles of Autophagy Induced by Natural Compounds in Prostate Cancer

V. Naponelli | A. Modernelli | ... | F. Rizzi
  • Special Issue
  • - Volume 2015
  • - Article ID 934207
  • - Review Article

Elaborating the Role of Natural Products-Induced Autophagy in Cancer Treatment: Achievements and Artifacts in the State of the Art

Ning Wang | Yibin Feng
  • Special Issue
  • - Volume 2015
  • - Article ID 352794
  • - Review Article

Calcium Homeostasis and ER Stress in Control of Autophagy in Cancer Cells

Elżbieta Kania | Beata Pająk | Arkadiusz Orzechowski
  • Special Issue
  • - Volume 2015
  • - Article ID 208076
  • - Clinical Study

Combined Epidermal Growth Factor Receptor and Beclin1 Autophagic Protein Expression Analysis Identifies Different Clinical Presentations, Responses to Chemo- and Radiotherapy, and Prognosis in Glioblastoma

Paolo Tini | Giuseppe Belmonte | ... | Luigi Pirtoli
  • Special Issue
  • - Volume 2015
  • - Article ID 459840
  • - Research Article

Gene Network Exploration of Crosstalk between Apoptosis and Autophagy in Chronic Myelogenous Leukemia

Fengfeng Wang | William C. S. Cho | ... | Benjamin Y. M. Yung
  • Special Issue
  • - Volume 2015
  • - Article ID 746092
  • - Research Article

Nucleofection of Rat Pheochromocytoma PC-12 Cells with Human Mutated Beta-Amyloid Precursor Protein Gene (APP-sw) Leads to Reduced Viability, Autophagy-Like Process, and Increased Expression and Secretion of Beta Amyloid

Beata Pająk | Elżbieta Kania | Arkadiusz Orzechowski
  • Special Issue
  • - Volume 2014
  • - Article ID 603980
  • - Review Article

Tumor Suppression and Promotion by Autophagy

Yenniffer Ávalos | Jimena Canales | ... | Andrew F. G. Quest
  • Special Issue
  • - Volume 2014
  • - Article ID 710345
  • - Review Article

The Importance of Autophagy Regulation in Breast Cancer Development and Treatment

Joanna Magdalena Zarzynska
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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