BioMed Research International

Cytotoxic T Lymphocytes and Vaccine Development 2013


Publishing date
05 Oct 2012
Status
Published
Submission deadline
18 May 2012

Lead Editor

1Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA

2Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA

3Department of Infectious Disease, College of Veterinary Medicine, China Agricultural University, Beijing 100094, China

4Center for Immunology, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA


Cytotoxic T Lymphocytes and Vaccine Development 2013

Description

As one of the major players in adaptive immunity, cytotoxic T lymphocytes (CTLs) play a critical role in the control of many infections and cancers. More importantly, induction of long-lasting functional CTLs has become a goal for the modern vaccination, especially for chronic infectious diseases. However, to achieve this goal, CTLs have to be appropriately activated and programmed. The molecular mechanisms of CTL activation are just starting to be understood and have been shown to be related to antigenic stimulation, expression of distinct costimulatory molecules, and inflammatory cytokines. In addition, provision of these stimuli may differ with distinct infections due to the tissue specificity of the pathogen, chronicity or persistence of antigen, differences in antigen presentation, and/or the cytokine milieu. By increasing our overall understanding of how these factors modulate CTL responses, we can design multifaceted vaccines which augment the development of functional, long-lasting memory CTLs in addition to neutralizing antibodies.

We invite authors to present original research articles as well as review articles that will stimulate the continuing efforts in defining the factors involved in CTL activation and the development of immunological memory. We are particularly interested in manuscripts that report the molecular mechanisms required for the development of effector and memory CTLs, CTL responses in specific infections in animals and humans, testing different strategies of memory CTL induction, and reports of new assays to evaluate CTL function. Reviews that summarize the results of latest discoveries and their implications on vaccination in economically important animals, the regulation of CTL responses by immune cells such as dendritic cells, CD4, and regulatory cells, and molecular mechanisms of CTL killing function are particularly welcome. Potential topics include, but are not limited to:

  • Molecular mechanisms of CTL activation and programming
  • Signal transduction for CTL migration
  • Regulation of CTL induction and function by regulatory cells
  • Regulation of CTL functions by manipulation of nutrition and metabolism
  • Regulatory CTLs
  • CTLs in cancer therapies
  • Molecular and epigenetic mechanisms of functional memory T-cell development
  • Characterization of CTL responses in infections in animals and humans
  • Novel vaccine approaches for the induction of functional memory CTLs
  • New assays for the evaluation of CTL activation

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jbb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 865314
  • - Editorial

Cytotoxic T Lymphocytes and Vaccine Development 2013

Zhengguo Xiao | Kim Klonowski | ... | Julie Curtsinger
  • Special Issue
  • - Volume 2013
  • - Article ID 976383
  • - Research Article

Characterization of CD8+ T-Cell Responses in the Peripheral Blood and Skin Injection Sites of Melanoma Patients Treated with mRNA Electroporated Autologous Dendritic Cells (TriMixDC-MEL)

Daphné Benteyn | An M. T. Van Nuffel | ... | Aude Bonehill
  • Special Issue
  • - Volume 2013
  • - Article ID 126189
  • - Research Article

IL-6 Production by Dendritic Cells Is Dispensable for CD8+ Memory T-Cell Generation

Jean-François Daudelin | Mélissa Mathieu | ... | Nathalie Labrecque
  • Special Issue
  • - Volume 2013
  • - Article ID 796014
  • - Research Article

Increased Toll-Like Receptor Signaling Pathways Characterize CD8+ Cells in Rapidly Progressive SIV Infection

Maria Cecilia Garibaldi Marcondes | Celsa Spina | ... | Howard Fox
  • Special Issue
  • - Volume 2013
  • - Article ID 492372
  • - Review Article

What Is Recent in Pancreatic Cancer Immunotherapy?

Elena Niccolai | Domenico Prisco | ... | Amedeo Amedei
  • Special Issue
  • - Volume 2013
  • - Article ID 871936
  • - Review Article

MUC1-Specific Cytotoxic T Lymphocytes in Cancer Therapy: Induction and Challenge

David Roulois | Marc Grégoire | Jean-François Fonteneau
  • Special Issue
  • - Volume 2013
  • - Article ID 924023
  • - Research Article

CpG and Interleukin-15 Synergize to Enhance IFN-γ Production by Activated CD8+ T Cells

Dustin Cobb | Siqi Guo | Ronald B. Smeltz
BioMed Research International
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Acceptance rate8%
Submission to final decision128 days
Acceptance to publication21 days
CiteScore5.300
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