Medical ultrasound can provide real-time dynamic images of the subjects, with substantially low cost and no harmful ionizing radiation. The portable ultrasound machine has been widely used in recent decades. The applications of medical ultrasound have been developed after decades of cooperative efforts from clinicians, researchers, and engineers. Rapidly developing fields include ultrasound neuromodulation, optical-acoustic imaging, musculoskeletal ultrasound, and super-resolution ultrasound imaging.

The aims of this special issue are to bring together clinical experts and ultrasound imaging researchers, practitioners, and health professionals and to report revolutionary advances in translational and emerging clinical applications. The topics of interest in this special issue include novel preclinical and clinical applications of medical ultrasound.

Potential topics include but are not limited to the following:

• Advances in high frequency/framerate ultrasound imaging
• Emerging materials/technologies in ultrasonic transducers
• Artificial Intelligence/machine learning in ultrasound imaging/image processing
• Ultrasound neuromodulation
• Optical-acoustic imaging
• Ultrasound elastography
• MR-guided focused ultrasound