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Congenital Anomalies of the Kidney and Urinary Tract in Children: from Genetics to Daily Clinical Practice

Call for Papers

Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease in childhood and contribute significantly to morbidity. Frequently, these anomalies are associated with congenital reduced nephron mass, which can predispose the patients to hypertension, chronic renal failure, and dialysis later in life.

CAKUT can currently be identified at prenatal ultrasound and during the first few months of life, and these children can therefore undergo diagnostic and therapeutic (medical or surgical) procedures early in life. However, it is important to not over- or undertreat these conditions. Therefore, pediatricians, neonatologists, urologists, and nephrologists in their daily clinical practice can face children with various forms of CAKUT which can present various degrees of nephron mass impairment. The challenge is preventing future impairment of the renal function as best as possible. In addition, it is important to identify those children with “obstructive pattern”, i.e., affected by posterior urethral valve or ureteropelvic junction obstruction. These patients can then be recommended for surgery before the establishment of kidney injury.

In recent years, knowledge regarding the genetics of CAKUT has increased. As a result, the medical approach to CAKUT in childhood is changing, allowing for more conservative diagnostic and therapeutic approaches to be utilized, in order to avoid radiation and surgical approaches with a high risk of developing complications. An interesting avenue for future research could focus on identifying precocious biomarkers or genetic markers able to identify children at risk of developing future chronic kidney disease. This may lead to developments in personalized therapy, in order to personalize follow-up treatments and avoid ineffective medical treatment for children with CAKUT.

This special issue invites researchers in this field to contribute original research and review articles, in order to collate the growing and current state-of-the-art knowledge on CAKUT. Submissions concerning all issues related to CAKUT are welcomed, such as genetics, diagnostic procedures, antibiotic prophylaxis, urinary tract infections, medical and surgical treatments, patient follow-up, and outcomes.

Potential topics include but are not limited to the following:

  • Vesicoureteral reflux
  • Posterior urethral valve
  • Multicystic dysplastic kidney
  • Unilateral renal agenesis
  • Ureteropelvic junction obstruction
  • Renal dysplasia
  • Vesicoureteral reflux nephropathy

Authors can submit their manuscripts through the Manuscript Tracking System at https://mts.hindawi.com/submit/journals/bmri/pediatrics/kutgd/.

Submission DeadlineFriday, 11 October 2019
Publication DateFebruary 2020

Papers are published upon acceptance, regardless of the Special Issue publication date.

Lead Guest Editor

  • Pierluigi Marzuillo, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, Italy

Guest Editors