Table of Contents Author Guidelines Submit a Manuscript

Immunomodulation in Orthopedic and Dental Tissue Engineering

Call for Papers

It has been found that immune cells play a vital role in orthopedic and dental biomaterials mediated-tissue regeneration. It is therefore of great clinical significance in developing biomaterials with favourable immunomodulatory properties to guide a beneficial immune environment for orthopedic and dental tissue regeneration. However, in terms of modulating immune cell responses, most of the research efforts have been put in developing bio-inert biomaterials to avoid unwanted foreign body reaction, while neglecting the importance of immune response in directing tissue regeneration. Via this special issue, the guest editors aim to change the traditional views on immunomodulation from “avoid” to “guide” the immune cell response. Advanced orthopedic and dental biomaterials should be able to educate the immune cells into generating a favourable immune environment for tissue regeneration. A paradigm shift of orthopedic and dental biomaterials from an inert to an immunomodulatory material should be informed, to highlight the important role of immune cells.

This special issue will provide the community with the opportunity to present the latest advances on biomaterials based strategy in immunomodulation and developing biomaterials with favourable immunomodulatory properties, while the core focus will be on preparation, structures, composites, morphology, and other physical properties of biomaterial and their effects on the immune response of cells.

Potential topics include but are not limited to the following:

  • Fabrication techniques in generating immunomodulatory biomaterials for orthopedic and dental applications
  • Effects of immune cells in orthopedic and dental tissue regeneration and the underlying mechanisms
  • The immune response towards different types of orthopedic and dental biomaterials
  • Biomaterials designed to manipulate the immune response and development of novel biomaterials with immunomodulatory properties
  • The effects of different physicochemical and mechanical properties of biomaterials on modulating the immune response

Authors can submit their manuscripts through the Manuscript Tracking System at

Manuscript DueFriday, 18 August 2017
First Round of ReviewsFriday, 10 November 2017
Publication DateFriday, 5 January 2018

Lead Guest Editor

  • Zetao Chen, Sun Yat-sen University, Guangzhou, China

Guest Editors

  • Jianglin Wang, Huazhong University of Science and Technology, Wuhan, China
  • Tong Li, University of Delaware, Newark, USA
  • Akash Bachhuka, University of Adelaide, Adelaide, Australia