BioMed Research International

Molecular Mechanisms of NAFLD in Metabolic Syndrome


Status
Published

1University of Porto, Porto, Portugal

2Institute of Agrochemistry and Food Technology, Valencia, Spain

3University of Bari Medical School, Bari, Italy


Molecular Mechanisms of NAFLD in Metabolic Syndrome

Description

Metabolic Syndrome (MetSyn), defined by central obesity, impaired glucose/insulin homeostasis, high blood pressure and atherogenic dyslipidemia, is increasing worldwide. Lifestyles play an important role as preventive determinants of MetSyn, conversely being potential inducers of MetSyn. Liver steatosis has been considered not only the hepatic MetSyn manifestation, but also one of the earliest MetSyn manifestations. Liver steatosis may stimulate inflammation that can further progress to cirrhosis and cancer [the entire spectrum of nonalcoholic fatty liver disease (NAFLD)].

We invite authors to submit original research and review articles, including basic and clinical studies that pursue the cross-talk between diet and/or physical exercise with central obesity, oxidative damage, endoplasmic reticulum stress, mitochondrial (dys)function, inflammation, insulin resistance, glucocorticoid excess, metabolic reprogramming, and gut microbiota in MetSyn features, particularly in NAFLD.

Potential topics include, but are not limited to:

  • Mechanisms by which high-fructose, high-fat and/or low-mineral diets induce NAFLD and MetSyn
  • Mechanisms by which physical exercise modulates NAFLD and MetSyn
  • Epigenetic mechanisms behind NAFLD and MetSyn
  • Diet and physical exercise-induced metabolic reprogramming in NAFLD and MetSyn
  • The role of physical exercise and diet in gut microbiota composition and activity
  • The role of gut microbiota in NAFLD and MetSyn
  • The role of physical exercise and diet in inflammation, oxidative damage, and endoplasmic reticulum stress
  • The role of inflammation, oxidative damage and endoplasmic reticulum stress in glucocorticoid and insulin pathways dysfunction in NAFLD and MetSyn
  • Mitochondrial (dys)function and endoplasmic reticulum stress in NAFLD and MetSyn
  • Visceral obesity in NAFLD and MetSyn: pathophysiological aspects and non- pharmacological therapeutic options
  • Lipid metabolism, insulin resistance, and mitochondrial (dys)function in NAFLD and MetSyn
  • New NAFLD and MetSyn-related phenotypes markers
  • Early life nutrition and the programming of NAFLD and MetSyn

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 621080
  • - Editorial

Molecular Mechanisms of NAFLD in Metabolic Syndrome

Maria João Martins | António Ascensão | ... | Piero Portincasa
  • Special Issue
  • - Volume 2015
  • - Article ID 979515
  • - Review Article

Gut Microbiota: Association with NAFLD and Metabolic Disturbances

E. Lau | D. Carvalho | P. Freitas
  • Special Issue
  • - Volume 2015
  • - Article ID 597134
  • - Review Article

The Dual Role of Nrf2 in Nonalcoholic Fatty Liver Disease: Regulation of Antioxidant Defenses and Hepatic Lipid Metabolism

Sílvia S. Chambel | Andreia Santos-Gonçalves | Tiago L. Duarte
  • Special Issue
  • - Volume 2015
  • - Article ID 839253
  • - Research Article

Nonalcoholic Fatty Liver Disease Relationship with Metabolic Syndrome in Class III Obesity Individuals

A. Cordeiro | S. E. Pereira | ... | A. Ramalho
  • Special Issue
  • - Volume 2015
  • - Article ID 984578
  • - Review Article

How Inflammation Impinges on NAFLD: A Role for Kupffer Cells

Nádia Duarte | Inês C. Coelho | ... | M. Paula Macedo
  • Special Issue
  • - Volume 2015
  • - Article ID 535982
  • - Research Article

Individual CLA Isomers, c9t11 and t10c12, Prevent Excess Liver Glycogen Storage and Inhibit Lipogenic Genes Expression Induced by High-Fructose Diet in Rats

Edyta Maslak | Elzbieta Buczek | ... | Renata B. Kostogrys
  • Special Issue
  • - Volume 2015
  • - Article ID 437107
  • - Review Article

Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life

Minglan Li | Clare M. Reynolds | ... | Mark H. Vickers
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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