BioMed Research International

Cardioprotection during Adult and Pediatric Open Heart Surgery


Publishing date
12 Dec 2014
Status
Published
Submission deadline
25 Jul 2014

1Bristol Heart Institute, Level 7, Bristol Royal Infirmary, Faculty of Medicine & Dentistry, University of Bristol, Bristol, UK

2Cardiothoracic Surgery, The Chinese University of Hong Kong, Faculty of Medicine, Prince of Wales Hospital, Shatin, New Territories, Hong Kong

3Cardiovascular Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan

4Congenital Heart Surgery, Royal Hospital for Children and University of Bristol, Level 7, Bristol Royal Infirmary, Marlborough Street, Bristol BS2 8HW, UK


Cardioprotection during Adult and Pediatric Open Heart Surgery

Description

Myocardial reperfusion damage following cardioplegic ischemic arrest is a key determinant of postoperative organ functional recovery, morbidity, and mortality in adult and pediatric patients undergoing open heart surgery. Despite recent advances in the design of cardioprotective strategies, the arrested heart still sustains significant injury. This is largely due to the fact that cardioprotective strategies do not take into account differences in pathology or age. Vulnerability of the diseased heart to ischemia and reperfusion is different for different pathologies or associated pathologies (e.g., coronary disease, hypertrophy, diabetes, etc.) and different age (neonate, infant, children, and adult). Additionally, the roles of triggers and mediators of cardiac cellular death for each pathology/age are not fully understood. This is important in order to design appropriate/optimal protective techniques. Ongoing strategies for myocardial protection include the inclusion of various additives that aim at reducing the damaging effects of ischemia and reperfusion (e.g., calcium overload, metabolic derangement, and accumulation of reactive oxygen species). Recent and novel strategies have also included gene and cell therapies.

We invite investigators to contribute original research articles and review articles that will address any of these issues. Potential topics include, but are not limited to:

  • Novel interventions in man or in clinically relevant experimental models
  • Molecular and cellular changes during cardiac insults which can be targeted for cardioprotection
  • New technologies or methods to study cardiac injury and to identify cardioprotective targets

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/surgery/capo/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 712721
  • - Editorial

Cardioprotection during Adult and Pediatric Open Heart Surgery

M-Saadeh Suleiman | Malcolm Underwood | ... | Massimo Caputo
  • Special Issue
  • - Volume 2015
  • - Article ID 515437
  • - Review Article

Monoamine Oxidases as Potential Contributors to Oxidative Stress in Diabetes: Time for a Study in Patients Undergoing Heart Surgery

Oana M. Duicu | Rodica Lighezan | ... | Cristian Mornos
  • Special Issue
  • - Volume 2015
  • - Article ID 680515
  • - Review Article

Changes in Heart Rate Variability after Coronary Artery Bypass Grafting and Clinical Importance of These Findings

Nenad Lakusic | Darija Mahovic | ... | Dusko Cerovec
  • Special Issue
  • - Volume 2015
  • - Article ID 718492
  • - Research Article

Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes

Myriam Cherif | Massimo Caputo | ... | Mohamed T. Ghorbel
  • Special Issue
  • - Volume 2015
  • - Article ID 256905
  • - Research Article

Endothelial Injury Associated with Cold or Warm Blood Cardioplegia during Coronary Artery Bypass Graft Surgery

Elmar W. Kuhn | Yeong-Hoon Choi | ... | Thorsten Wahlers
  • Special Issue
  • - Volume 2014
  • - Article ID 678268
  • - Review Article

Normoxic and Hyperoxic Cardiopulmonary Bypass in Congenital Heart Disease

Amir Mokhtari | Martin Lewis
  • Special Issue
  • - Volume 2014
  • - Article ID 325725
  • - Review Article

Cardioprotection: A Review of Current Practice in Global Ischemia and Future Translational Perspective

Andreas Habertheuer | Alfred Kocher | ... | Dominik Wiedemann
  • Special Issue
  • - Volume 2014
  • - Article ID 601250
  • - Research Article

Propofol Protects the Immature Rabbit Heart against Ischemia and Reperfusion Injury: Impact on Functional Recovery and Histopathological Changes

Makoto Shirakawa | Hajime Imura | Takashi Nitta
  • Special Issue
  • - Volume 2014
  • - Article ID 808096
  • - Review Article

Adjuvant Cardioprotection in Cardiac Surgery: Update

Robert Wagner | Pavel Piler | ... | Peter Kruzliak
  • Special Issue
  • - Volume 2014
  • - Article ID 536510
  • - Research Article

Insulin Preconditioning Elevates p-Akt and Cardiac Contractility after Reperfusion in the Isolated Ischemic Rat Heart

Tamaki Sato | Hiroaki Sato | ... | Thomas Schricker
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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