BioMed Research International

Experimental Heart Failure Models and Their Pathophysiological Characterization


Status
Published

1University Heart Centre Hamburg Eppendorf, Hamburg, Germany

2University of Alberta, Edmonton, Canada

3University College Dublin, Dublin, Ireland

4University of Heidelberg, Heidelberg, Germany


Experimental Heart Failure Models and Their Pathophysiological Characterization

Description

Experimental models of heart failure can be used to address specific questions not easily answered in patients. However, no single model can reproduce exactly any of the clinical syndromes of heart failure. A number of animal models that mimic heart failure exits will be discussed in this special issue. Besides some naturally occuring models, heart failure can be induced by acute or chronic coronary occlusion, coronary artery embolization, pressure overload (transverse aortic constriction), and volume overload (induction of arteriovenous shunts). Additional models include the induction of heart failure by applying toxic agents or viral infection. Recently, genetically manipulated animals that develop heart failure are getting more and more common and becoming important.

Experimental models of myocardial infarction or destruction are likely to be the most suitable for assessing novel therapy provided that peripheral reflexes are maintained. However, experimental heart failure models are especially useful in the study of ventricular hypertrophy, cellular derangements, vascular changes, and hormone and electrolyte disturbances.

We invite investigators to contribute original research articles as well as review articles that will help in understanding the pathology and hemodynamic effects in various experimental models mimicing different entities of heart failure. Both experimental and theoretical papers are welcome.

Potential topics include, but are not limited to:

  • Identification of novel experimental right and left ventricular heart failure models and their translation into the clinical setting
  • Experimental models for heart failure with preserved ejection fraction and diastolic dysfunction and their translation to its clinical syndrome
  • Gender-specific impact in experimental heart failure models in different species
  • Genetic-induced heart failure models in different species
  • Hemodynamic characterization under basal and stress-induced conditions (e.g., echocardiography, conductance catheter technique, and MRI) and its methodical accuracy in heart failure models
  • Aging-related experimental heart failure models and their impact on myocardial fibrosis and aging-related pathways
  • Strategies in planning a valuable experimental study design

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 2538263
  • - Editorial

Experimental Heart Failure Models and Their Pathophysiological Characterization

Peter Moritz Becher | Bodh I. Jugdutt | ... | Bastian Schmack
  • Special Issue
  • - Volume 2015
  • - Article ID 465342
  • - Research Article

An Upgrade on the Rabbit Model of Anthracycline-Induced Cardiomyopathy: Shorter Protocol, Reduced Mortality, and Higher Incidence of Overt Dilated Cardiomyopathy

Jesús Talavera | Alejandro Giraldo | ... | Jose M. Moraleda
  • Special Issue
  • - Volume 2015
  • - Article ID 467597
  • - Review Article

Relevance of the Carotid Body Chemoreflex in the Progression of Heart Failure

David C. Andrade | Claudia Lucero | ... | Rodrigo Del Rio
  • Special Issue
  • - Volume 2015
  • - Article ID 949624
  • - Research Article

Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism

Elise Roussel | Marie-Claude Drolet | ... | Marie Arsenault
  • Special Issue
  • - Volume 2015
  • - Article ID 409350
  • - Research Article

Angiotensinase C mRNA and Protein Downregulations Are Involved in Ethanol-Deteriorated Left Ventricular Systolic Dysfunction in Spontaneously Hypertensive Rats

Jinyao Liu | Ayako Hakucho | Tatsuya Fujimiya
  • Special Issue
  • - Volume 2015
  • - Article ID 539805
  • - Research Article

Neonatal Death and Heart Failure in Mouse with Transgenic HSP60 Expression

Tsung-Hsien Chen | Shan-Wen Liu | ... | Kurt Ming-Chao Lin
  • Special Issue
  • - Volume 2015
  • - Article ID 893051
  • - Research Article

Comparative Analysis of Methods to Induce Myocardial Infarction in a Closed-Chest Rabbit Model

Marc-Antoine Isorni | Amaury Casanova | ... | Philippe Menasche
  • Special Issue
  • - Volume 2015
  • - Article ID 753210
  • - Research Article

Novel Model of Pulmonary Artery Banding Leading to Right Heart Failure in Rats

Masataka Hirata | Daiki Ousaka | ... | Shunji Sano
  • Special Issue
  • - Volume 2015
  • - Article ID 163564
  • - Research Article

Pressure Overload by Transverse Aortic Constriction Induces Maladaptive Hypertrophy in a Titin-Truncated Mouse Model

Qifeng Zhou | Scott Kesteven | ... | Richard P. Harvey
BioMed Research International
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Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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