BioMed Research International

Carbapenemases in Gram-Negative Bacteria


Publishing date
28 Mar 2014
Status
Published
Submission deadline
08 Nov 2013

Lead Editor

1Clinical Department of Clinical and Molecular Microbiology, School of Medicine, University Hospital Center Zagreb, Kispatic Street 12, 10000 Zagreb, Croatia

2Department of Microbiology, University Hospital Split, Spinčić Street 21, Split, Croatia

3Cantonal Institute of Public Health, Zenica, Bosnia and Herzegovina

4Department of Microbiology, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia


Carbapenemases in Gram-Negative Bacteria

Description

Emergence of carbapenemases in Enterobacteriaceae and nonfermentative bacteria poses a serious therapeutic problem in hospitals because carbapenems are often antibiotics of last resort for the treatment of serious infections caused by multidrug resistant gram-negative bacteria. Acquired carbapenemases belong to group A (IMI, NMC, SME GES, and KPC), group B (metallo-β-lactamases of VIM, IMP, GIM, NDM, SIM, and DIM series), and group D (carbapenem hydrolyzing oxacillinases). β-Lactamase-mediated resistance to carbapenems has been reported in Enterobacteriacea mostly due to the expression of class A KPC β-lactamases susceptible to the inhibition by clavulanic acid, class B metallo-β-lactamases (IMP or VIM), or OXA-48 β-lactamase belonging to class D β-lactamases. Furthermore, carbapenem resistance can be mediated by hyperproduction of ESBLs or plasmid-mediated AmpC β-lactamases combined with porin loss. Carbapenemases found in Acinetobacter belong to molecular class D (OXA enzymes) or class B (metallo-β-lactamases of IMP, VIM, or SIM family). Accurate and fast laboratory identification of carbapenemases is important to prevent therapeutic failures and nosocimal outbreaks.

We particularly take an interest in manuscripts that report relevance of carbapenemases in clinical and laboratory practice. Manuscripts that summarize the results of laboratory characterization of carbapenemases in different gram-negative bacteria such as Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii are welcome. Potential topics include, but are not limited to:

  • Molecular epidemiology of carbapenemase producing Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii
  • Mechanisms of carbapenem resistance in Enterobacteriaceae, P. aeruginosa, and A. baumannii
  • Laboratory characterization of carbapenemases
  • Clinical impact of carbapenem resistance

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/microbiology/gnb/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 841951
  • - Editorial

Carbapenemases in Gram-Negative Bacteria: Laboratory Detection and Clinical Significance

Branka Bedenić | Vanda Plečko | ... | Karmen Godič Torkar
  • Special Issue
  • - Volume 2014
  • - Article ID 305784
  • - Review Article

Epidemiology of Carbapenemase-Producing Enterobacteriaceae and Acinetobacter baumannii in Mediterranean Countries

Nassima Djahmi | Catherine Dunyach-Remy | ... | Jean-Philippe Lavigne
  • Special Issue
  • - Volume 2014
  • - Article ID 139305
  • - Research Article

Performance of Quantification of Modified Hodge Test: An Evaluation with Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae Isolates

Vanessa Bley Ribeiro | Adriano Rostirolla Linhares | ... | Afonso Luis Barth
  • Special Issue
  • - Volume 2014
  • - Article ID 249856
  • - Review Article

Worldwide Dissemination of the NDM-Type Carbapenemases in Gram-Negative Bacteria

Laurent Dortet | Laurent Poirel | Patrice Nordmann
  • Special Issue
  • - Volume 2014
  • - Article ID 548960
  • - Research Article

Detection of Carbapenemase-Producing Enterobacteriaceae in the Baltic Countries and St. Petersburg Area

Anastasia Pavelkovich | Arta Balode | ... | Paul Naaber
  • Special Issue
  • - Volume 2014
  • - Article ID 303104
  • - Research Article

Carbapenemase Genes among Multidrug Resistant Gram Negative Clinical Isolates from a Tertiary Hospital in Mwanza, Tanzania

Martha F. Mushi | Stephen E. Mshana | ... | Freddie Bwanga
  • Special Issue
  • - Volume 2014
  • - Article ID 101635
  • - Research Article

Antimicrobial Resistance Pattern and Their Beta-Lactamase Encoding Genes among Pseudomonas aeruginosa Strains Isolated from Cancer Patients

Mai M. Zafer | Mohamed H. Al-Agamy | ... | Mohammed Seif El-Din Ashour
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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