BioMed Research International

Protein Acetylation and the Physiological Role of HDACs


Publishing date
15 Jan 2011
Status
Published
Submission deadline
15 Jul 2010

1Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4002 Basel, Switzerland

2Department of Medical Biochemistry, Medical University Vienna, Dr. Bohrgasse 9, 1030 Vienna, Austria

3Chemical Genetics Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan


Protein Acetylation and the Physiological Role of HDACs

Description

In the recent years, lysine acetylation in histones as well as nonhistone proteins has been much studied and it became clear that this protein modification plays major regulatory roles in eukaryotes. In histones, acetylation is usually associated with gene activity and deacetylation with reduced expression or formation of heterochromatin. Acetylation/deacetylation of nonhistone proteins can impact multiple aspects of protein function/activity, such as stability, cellular localization, or capacity to bind to DNA, to name only a few. Acetylation is catalyzed by (histone) acetyltransferases (HATs) and deacetylation is carried on by (histone) deacetylases (HDACs). Chemical inhibitors of HDACs have been identified early on and this has greatly helped to get insights into the roles of these enzymes. Importantly, HDAC inhibitors have been shown to be beneficial in very diverse pathological situations, ranging from cancer to neurodegeneration or autoimmunity, and two inhibitors have already been FDA approved for the treatment of cutaneous T-cell leukemia. In most cases however, the mechanisms and/or the enzymes involved have not been identified.

The main focus of this special issue will be to review the status of protein acetylation in relation to normal cellular or organismal physiology and pathologic situations, with an emphasis on HDACs. We will also address novel insights gained from global analysis of lysine acetylation.

The topics to be covered include, but are not limited to:

  • HDAC, HATs, and Sirtuin families
  • HDACs (and HATs) in chromatin and epigenetic regulation
  • HDACs (and HATs) in nonhistone proteins regulation
  • HDACs in cell cycle regulation
  • Physiological role of HDACs based on knockout models
  • HDACs in disease: cancer and other models
  • Global analysis of acetylation

Before submission, authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jbb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 148201
  • - Editorial

Protein Acetylation and the Physiological Role of HDACs

Patrick Matthias | Christian Seiser | Minoru Yoshida
  • Special Issue
  • - Volume 2011
  • - Article ID 368276
  • - Review Article

Sirtuins: Molecular Traffic Lights in the Crossroad of Oxidative Stress, Chromatin Remodeling, and Transcription

Ramkumar Rajendran | Richa Garva | ... | Constantinos Demonacos
  • Special Issue
  • - Volume 2011
  • - Article ID 835968
  • - Review Article

Histone Deacetylases in Neural Stem Cells and Induced Pluripotent Stem Cells

Guoqiang Sun | Chelsea Fu | ... | Yanhong Shi
  • Special Issue
  • - Volume 2011
  • - Article ID 514261
  • - Review Article

Therapeutic Strategies to Enhance the Anticancer Efficacy of Histone Deacetylase Inhibitors

Claudia P. Miller | Melissa M. Singh | ... | Joya Chandra
  • Special Issue
  • - Volume 2011
  • - Article ID 830260
  • - Review Article

Autophagic and Apoptotic Effects of HDAC Inhibitors on Cancer Cells

Hidemi Rikiishi
  • Special Issue
  • - Volume 2011
  • - Article ID 214143
  • - Review Article

Myelodysplastic Syndrome and Histone Deacetylase Inhibitors: “To Be or Not to Be Acetylated”?

Sebastian Stintzing | Ralf Kemmerling | ... | Daniel Neureiter
  • Special Issue
  • - Volume 2011
  • - Article ID 523481
  • - Review Article

Modulation of Acetylation: Creating a Pro-survival and Anti-Inflammatory Phenotype in Lethal Hemorrhagic and Septic Shock

Yongqing Li | Hasan B. Alam
  • Special Issue
  • - Volume 2011
  • - Article ID 148046
  • - Review Article

The Role of HDACs Inhibitors in Childhood and Adolescence Acute Leukemias

Riccardo Masetti | Salvatore Serravalle | ... | Andrea Pession
  • Special Issue
  • - Volume 2011
  • - Article ID 924898
  • - Review Article

Elongator: An Ancestral Complex Driving Transcription and Migration through Protein Acetylation

Catherine Creppe | Marcus Buschbeck
  • Special Issue
  • - Volume 2011
  • - Article ID 640610
  • - Review Article

Histone Acetyltransferases as Regulators of Nonhistone Proteins: The Role of Interferon Regulatory Factor Acetylation on Gene Transcription

Atsuko Masumi
BioMed Research International
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