BioMed Research International

Molecular Markers in the Diagnosis and Treatment of Cancer


Status
Published

Lead Editor

1University of Arkansas for Medical Sciences, Little Rock, USA

2Autonomous University of Barcelona, Barcelona, Spain


Molecular Markers in the Diagnosis and Treatment of Cancer

Description

Genetic alterations have been identified in many disease processes, including a variety of neoplasms. As more of these alterations are being discovered, their significance in some diseases remains obscure, while they have become diagnostic genetic signatures for others. In addition, increasingly growing numbers of these alterations are now the subject of targeted therapies. They can also provide significant prognostic and predictive information, further blurring the boundaries between diagnosis and treatment, as well as basic and clinical sciences. Of paramount importance are the developments in our understanding of genetic aspects of disease and the explosion of knowledge in molecular biology. The latter has been translated into clinical application in the form of molecular diagnostics, involving high technology testing. Altogether, we have a better understanding of how such alterations operate in the process of oncogenesis, which in turn helps us to better diagnose and treat neoplasms based on these alterations. O6-methylguanine DNA methyltransferase (MGMT) gene methylation status in glioblastoma and response to alkylating agents, c-kit mutations in gastrointestinal stromal tumor (GIST) and ALK gene rearrangements in ALK-positive anaplastic large cell lymphoma, mutations of tumor suppressor genes, and gefitinib targeting epidermal growth factor receptor (EGFR) in nonsmall cell lung cancer are examples of how genetic alterations, identified by molecular diagnostic testing, can impact all aspects of neoplasia, from oncogenesis to treatment.

As such, we are particularly interested in manuscripts that report technical, basic, and clinical research, molecular biology, diagnostic and therapeutic aspects of neoplasia, and clinical trials involving these topics, as well as review papers on any of these subjects. The topics are not limited to a particular organ, system, or type of neoplasia; however, the main purpose is to compile an issue composed of manuscripts that emphasize the molecular markers in such aspects of neoplasia in an attempt to provide the reader with an up-to-date source of current research on the state of molecular markers.

Potential topics include, but are not limited to:

  • Molecular diagnostic techniques
  • Oncogenesis
  • Diagnostic markers of cancer
  • Prognostic and predictive markers of cancer
  • Molecularly targeted therapies and drug discovery
  • Personalized medicine and molecular markers

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 528304
  • - Research Article

Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses

Kazuya Matsumoto | Yohei Takeda | ... | Yoshikazu Murawaki
  • Special Issue
  • - Volume 2015
  • - Article ID 105217
  • - Editorial

Molecular Markers in the Diagnosis and Treatment of Cancer

Murat Gokden | Aurelio Ariza | Konstantinos Arnaoutakis
  • Special Issue
  • - Volume 2015
  • - Article ID 486391
  • - Clinical Study

BRAF Testing in Multifocal Papillary Thyroid Carcinoma

Hillary Z. Kimbrell | Andrew B. Sholl | ... | Emad Kandil
  • Special Issue
  • - Volume 2015
  • - Article ID 306964
  • - Research Article

Circulating Galectin-1 and 90K/Mac-2BP Correlated with the Tumor Stages of Patients with Colorectal Cancer

Keng-Liang Wu | Hong-Hwa Chen | ... | Kuender D. Yang
  • Special Issue
  • - Volume 2015
  • - Article ID 641023
  • - Research Article

The Diagnostic Ability of Follow-Up Imaging Biomarkers after Treatment of Glioblastoma in the Temozolomide Era: Implications from Proton MR Spectroscopy and Apparent Diffusion Coefficient Mapping

Martin Bulik | Tomas Kazda | ... | Radim Jancalek
  • Special Issue
  • - Volume 2015
  • - Article ID 131685
  • - Research Article

Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival

Sandra F. Martins | Ricardo Amorim | ... | Adhemar Longatto-Filho
  • Special Issue
  • - Volume 2015
  • - Article ID 340732
  • - Review Article

The Emergent Landscape of Detecting EGFR Mutations Using Circulating Tumor DNA in Lung Cancer

Wei-Lun Huang | Fang Wei | ... | Wu-Chou Su
  • Special Issue
  • - Volume 2015
  • - Article ID 303987
  • - Review Article

Potential Role of MicroRNA-210 as Biomarker in Human Cancers Detection: A Meta-Analysis

Jiongjiong Lu | Feng Xie | ... | Jiamei Yang
  • Special Issue
  • - Volume 2015
  • - Article ID 614845
  • - Research Article

Metastatic Salivary Gland Tumors: A Single-Center Study Demonstrating the Feasibility and Potential Clinical Benefit of Molecular-Profiling-Guided Therapy

Aron Popovtzer | Michal Sarfaty | ... | Salomon M. Stemmer
  • Special Issue
  • - Volume 2015
  • - Article ID 294213
  • - Review Article

Inverse Association between Prediagnostic IgE Levels and the Risk of Brain Tumors: A Systematic Review and Meta-Analysis

Chong Ma | Lei Cao | ... | Hongsheng Xu
BioMed Research International
 Journal metrics
Acceptance rate30%
Submission to final decision70 days
Acceptance to publication36 days
CiteScore2.410
Impact Factor2.197
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