BioMed Research International

Biomechanical Properties of Biomaterials/Scaffolds for Bone Tissue Regeneration


Publishing date
01 Nov 2019
Status
Closed
Submission deadline
05 Jul 2019

1IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

2AO Research Institute Davos, Davos, Switzerland

This issue is now closed for submissions.
More articles will be published in the near future.

Biomechanical Properties of Biomaterials/Scaffolds for Bone Tissue Regeneration

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Bone is a mineralized connective tissue, with a unique trauma healing potential. However, the replacement or regeneration of lost bone is not always successful and can become more complex the larger the bone defect. Therefore, even with this healing property, biomaterials/scaffolds are required in many situations. Several bone diseases, such as osteoporosis, osteoarthritis, malignant osteolysis, osteomyelitis, and their related orthopedic procedures (such as pseudo-arthrosis chirurgical treatment, hip or knee arthroplasty, arthrodesis, and tumor removal) commonly require biomaterials/scaffolds to augment bone repair and regeneration. To date, numerous preclinical and clinical studies have explored different types of biomaterials (metallic, polymeric, ceramic, or composites) loaded with cells (mainly mesenchymal stem cell), biological cues (such as growth factors, platelet lysates, hormones, and phytohormones) or with different types of drugs, mainly evaluating their osteoconductive and osteoinductive properties to regenerate damaged bone tissue.

However, optimum tissue regeneration performance of bone biomaterials/scaffolds is also dependent on their biomechanical behavior. In fact, the biomechanical properties of biomaterials/scaffolds that are employed in bone tissue engineering and/or bone substitution have been shown to significantly influence the cellular response and bone tissue regeneration rate. Biomaterials/scaffolds with unsatisfactory biomechanical properties are not able to provide enough mechanical support for bone tissue regeneration in load-bearing applications, while overly stiff biomaterials could prevent bone tissue regeneration through the stress-shielding phenomenon. Various methodologies have therefore been set up to evaluate and characterize the biomechanical properties of biomaterials/scaffolds used for bone tissue regeneration. As part of this evaluation, one of the most important questions is “what are the desired biomechanical properties?” The simplest answer would be “the biomechanical properties of the native tissue”. Although this answer provides a good starting point, it should be noted that the ultimate biomechanical properties of the native tissue are not necessarily the ones that optimize the tissue regeneration performance of scaffolds in vivo. Due to an increasingly aging population and the associated increased risk of bone diseases, there is currently a significant interest in the medical community to have “biomechanical competent” biomaterials/scaffolds for bone tissue regeneration.

This special issue aims to collect original research articles and reviews on recent preclinical and clinical findings regarding biomechanical properties of biomaterials/scaffolds for bone (cortical and cancellous) tissue regeneration in the field of orthopedics.

Potential topics include but are not limited to the following:

  • Preclinical (in vitro and in vivo) evaluation of biomechanical properties of biomaterials/scaffolds in bone tissue regeneration
  • Biomechanical characteristics of biomaterials/scaffolds for the repair of osteochondral defects
  • Biomechanical characteristics of bone substitutes
  • Biomechanical properties of custom-made devices
  • Biomechanical effects of using different drugs (antibiotic, antitumoral, and antiresorptive) in biomaterials/scaffolds
  • Mechanical properties and hierarchical structures of well-studied and newly-studied biomimetic and bioinspired materials in bone tissue regeneration
  • Computational biomechanical aspects of biomaterials/scaffolds in bone tissue regeneration
  • Biomechanics and in silico medicine
  • Biomechanical, histological, histomorphometric, and microtomographic studies of bone regeneration after a biomaterial/scaffold implant

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 1804630
  • - Review Article

Histological, Histomorphometrical, and Biomechanical Studies of Bone-Implanted Medical Devices: Hard Resin Embedding

M. Maglio | F. Salamanna | ... | M. Fini
  • Special Issue
  • - Volume 2019
  • - Article ID 2076138
  • - Research Article

Fabrication and In Vitro Evaluation of 3D Printed Porous Polyetherimide Scaffolds for Bone Tissue Engineering

Xiongfeng Tang | Yanguo Qin | ... | Ruiyan Li
  • Special Issue
  • - Volume 2019
  • - Article ID 2797210
  • - Clinical Study

In Situ Endoscopic Analysis of Vascular Supply and Regenerated Alveolar Bone in β-TCP Grafted and Ungrafted Postextraction Sites before Implant Placement: A Prospective Case Control Study

Víctor Beltrán | Marcio Lazzarini | ... | Wilfried Engelke
  • Special Issue
  • - Volume 2019
  • - Article ID 2656503
  • - Clinical Study

Reconstruction of Medial Wall Blowout Fracture Defect with a Combination of Resorbable Meshed Plate and Cancellous Bone Allograft

Jongweon Shin | Song I Park | ... | Hyung-Sup Shim
  • Special Issue
  • - Volume 2019
  • - Article ID 4040236
  • - Review Article

Current Trends in the Evaluation of Osteochondral Lesion Treatments: Histology, Histomorphometry, and Biomechanics in Preclinical Models

M. Maglio | S. Brogini | ... | M. Tschon
  • Special Issue
  • - Volume 2019
  • - Article ID 8483658
  • - Clinical Study

Observational Study on the Preparation of the Implant Site with Piezosurgery vs. Drill: Comparison between the Two Methods in terms of Postoperative Pain, Surgical Times, and Operational Advantages

Michele Maglione | Lorenzo Bevilacqua | ... | Antonio Scarano
  • Special Issue
  • - Volume 2019
  • - Article ID 2587245
  • - Review Article

The Additional Effect of Autologous Platelet Concentrates to Coronally Advanced Flap in the Treatment of Gingival Recessions: A Systematic Review and Meta-Analysis

Rong Li | Yanqing Liu | ... | Dongmei Zhang
  • Special Issue
  • - Volume 2019
  • - Article ID 1680158
  • - Research Article

Evaluation of Implant Success in Patients with Dental Aplasia

Sameh Attia | Ella Schaper | ... | Jan-Falco Wilbrand
  • Special Issue
  • - Volume 2019
  • - Article ID 3210530
  • - Research Article

Cytokine Regulation from Human Peripheral Blood Leukocytes Cultured In Vitro with Silver Doped Bioactive Glasses Microparticles

Jefferson Muniz de Lima | Edlainne Pinheiro Ferreira | ... | Lúcio Roberto Cançado Castellano
  • Special Issue
  • - Volume 2019
  • - Article ID 3610785
  • - Research Article

Evaluation and Prediction of Mass Transport Properties for Porous Implant with Different Unit Cells: A Numerical Study

Jian Li | Diansheng Chen | Yubo Fan
BioMed Research International
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Acceptance rate30%
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CiteScore3.600
Impact Factor2.276
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