BioMed Research International

Cell and Molecular Mechanics in Health and Disease


Publishing date
27 Jan 2017
Status
Published
Submission deadline
09 Sep 2016

Lead Editor

1Konan University, Kobe, Japan

2Riken, Osaka, Japan

3University of Waterloo, Waterloo, Canada

4Nagoya University, Nagoya, Japan


Cell and Molecular Mechanics in Health and Disease

Description

A growing body of research has revealed that not only chemical stimuli, but also the mechanical microenvironment surrounding cells have a significant impact on cell behavior. Mechanical stimuli from the environment are detected by various mechanosensing biomolecules including mechanosensitive ion channels and nonchannel type mechanosensors, which lead to modulation of intracellular signaling. Notably, while subcellular structures—including the cytoskeleton, membranous organelles, and the nucleus—influence cell mechanics, the mechanical properties of both cells and their microenvironment are altered in cancer or other diseases such as chronic inflammation and muscle dystrophies. The abnormal expression and activation of mechanosensing biomolecules or components of these subcellular structures, which are sometimes accompanied by gene mutations, have been observed in many disease states. Such alterations potentially tune the chemical and physical interactions between cells and their environment and thereby contribute to disease progression. Therefore, the mechanical properties of individual subcellular structures (e.g., the actin cytoskeleton, cell adhesion complexes, and chromosomes) and signaling molecules regulating these structures are emerging as targets in the research.

The purpose of this special issue is to publish original research papers as well as review articles addressing how the mechanical properties of subcellular structures are altered in the diseases and how these alterations relate to the cell behaviors. A particular interest will be given to papers discussing the molecular mechanisms that regulate subcellular structures at the onset of and/or in the progression phases of diseases. Furthermore, papers reporting significant responses of cells against various mechanical environments are also appropriate.

Potential topics include, but are not limited to:

  • Mechanosensing and mechanotransduction in healthy and diseased cells
  • Functions and mechanisms of mechanosensitive ion channels and nonchannel type mechanosensors
  • Mechanical properties of extracellular microenvironment
  • Signal transduction regulating cellular/subcellular structures and mechanics
  • Cytoskeleton and cell adhesion in healthy and diseased cells
  • Dynamics and mechanics of nucleus and chromosome
  • Gene mutation affecting mechanics and behaviors of cells
  • Mechanobiology in gene and drug delivery
  • Tumorigenesis and tumor progression
  • Invasion and metastasis of cancer cells
  • Mechanotherapy of diseases

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 2860241
  • - Editorial

Cell and Molecular Mechanics in Health and Disease

Keiko Kawauchi | Hideaki Fujita | ... | Hiroaki Hirata
  • Special Issue
  • - Volume 2017
  • - Article ID 7804251
  • - Research Article

Directional Transport of a Bead Bound to Lamellipodial Surface Is Driven by Actin Polymerization

Daisuke Nobezawa | Sho-ichi Ikeda | ... | Hidetake Miyata
  • Special Issue
  • - Volume 2017
  • - Article ID 8701801
  • - Research Article

Hyperforin/HP-β-Cyclodextrin Enhances Mechanosensitive Ca2+ Signaling in HaCaT Keratinocytes and in Atopic Skin Ex Vivo Which Accelerates Wound Healing

Hiroya Takada | Jun Yonekawa | ... | Masahiro Sokabe
  • Special Issue
  • - Volume 2017
  • - Article ID 5158961
  • - Research Article

Substrate Stiffness Influences Doxorubicin-Induced p53 Activation via ROCK2 Expression

Takahiro Ebata | Yasumasa Mitsui | ... | Keiko Kawauchi
  • Special Issue
  • - Volume 2016
  • - Article ID 5749749
  • - Research Article

Dynamics of Actin Stress Fibers and Focal Adhesions during Slow Migration in Swiss 3T3 Fibroblasts: Intracellular Mechanism of Cell Turning

Michiko Sugawara | Hiromi Miyoshi | ... | Hao Liu
  • Special Issue
  • - Volume 2016
  • - Article ID 7969286
  • - Review Article

The Hedgehog Signaling Networks in Lung Cancer: The Mechanisms and Roles in Tumor Progression and Implications for Cancer Therapy

Yoshinori Abe | Nobuyuki Tanaka
  • Special Issue
  • - Volume 2016
  • - Article ID 1801403
  • - Research Article

A Two-Dimensional Numerical Investigation of Transport of Malaria-Infected Red Blood Cells in Stenotic Microchannels

Tong Wang | Yong Tao | ... | Zhongwen Xing
  • Special Issue
  • - Volume 2016
  • - Article ID 5959721
  • - Review Article

Roles of pRB in the Regulation of Nucleosome and Chromatin Structures

Chiharu Uchida
  • Special Issue
  • - Volume 2016
  • - Article ID 2401657
  • - Research Article

Voltage-Dependent Inactivation of MscS Occurs Independently of the Positively Charged Residues in the Transmembrane Domain

Takeshi Nomura | Masahiro Sokabe | Kenjiro Yoshimura
  • Special Issue
  • - Volume 2016
  • - Article ID 9231057
  • - Review Article

Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton Remodeling

Takahiro Ebata | Hiroaki Hirata | Keiko Kawauchi
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision77 days
Acceptance to publication52 days
CiteScore2.410
Impact Factor2.197
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