BioMed Research International

Cancer Immunology and Immunotherapy


Status
Published

Lead Editor

1Aligarh Muslim University, Aligarh, India

2University of California, Oakland, USA

3Cornell University, Ithaca, USA


Cancer Immunology and Immunotherapy

Description

Unravelling molecular and cellular liaison between immune system and cancer cells is gaining tremendous momentum across the globe. The gamut of genetics and epigenetics changes occurring in tumors provides diverse set of antigenic repertoire that host’s immune system can exploit to distinguish tumour versus their normal healthy counterparts. Intriguingly, an insight in their conceptual and technical footing paves the way to discover innovative cancer immunotherapy modes. Of late the area of cancer immunotherapies has been the subject of rigorous investigations and likely to hold the forefront of cancer therapy. There is in general consensus that cytotoxic T cells (CTLs) play cardinal role in antitumor immunity. However, accumulating evidence both from clinical and animal studies advocates that activation of the CTL immune effector arm alone is inadequate to mediate effective anticancer immunity. This has led a paradigm shift from activation of CTL immunity alone to activation of T helper cell immune response alone or in harmony with CTL to impart protective antitumor immunity. Furthermore, recently it has been increasingly recognized that cancer cells recruit Treg cells to inhibit antitumor immunity and have great implications in limiting the efficacy of the immunotherapeutic strategies; thus inhibition/depletion of Treg cells is entailed for harnessing the benefits of immunotherapies.

We invite researchers to contribute their original research articles as well as literature reviews to accelerate progressing efforts to explore potential of the immune system to turn the tide against this dreadful disease. We are interested in articles that explore facet of antitumor immunity and their application to immunotherapeutic strategies for the benefit of the cancer clientele.

Potential topics include, but are not limited to:

  • Identification of biomarkers of protective immunity against cancer
  • Illuminating the role of host factors in the development of antitumor immunity
  • Elucidation and characterization of tumor antigens as potential contenders in cancer prophylaxis or as potential targets in cancer immunotherapy
  • Strategies exploited to stimulate effector Th cells and inhibit Treg cells to achieve effective antitumor immunity
  • Recent developments in immunotherapeutic strategies with special convergence on prophylactic/therapeutic vaccines and combinatorial therapeutic approaches
  • Clinical investigations with relevance to tumor immunology and immunotherapies

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 393454
  • - Editorial

Cancer Immunology and Immunotherapy

Mohammad Owais | Swaleha Zubair | ... | Yung-Fu Chang
  • Special Issue
  • - Volume 2015
  • - Article ID 183523
  • - Research Article

Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study

Michele L. Santangelo | Carmen Criscitiello | ... | Nicola Carlomagno
  • Special Issue
  • - Volume 2015
  • - Article ID 717530
  • - Review Article

Dendritic Cell-Based Immunotherapy Treatment for Glioblastoma Multiforme

Liu Yang | Geng Guo | ... | Jing Liu
  • Special Issue
  • - Volume 2015
  • - Article ID 820813
  • - Review Article

Immunotherapy for Bone and Soft Tissue Sarcomas

Takenori Uehara | Tomohiro Fujiwara | ... | Heiichiro Udono
  • Special Issue
  • - Volume 2015
  • - Article ID 604385
  • - Research Article

Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma

Wan-Jhen Wang | Yu-Sheng Wu | ... | Shiu-Nan Chen
  • Special Issue
  • - Volume 2015
  • - Article ID 948501
  • - Review Article

Human Tumor Antigens and Cancer Immunotherapy

Nathalie Vigneron
  • Special Issue
  • - Volume 2015
  • - Article ID 178698
  • - Review Article

NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma

Cinzia Fionda | Alessandra Soriani | ... | Marco Cippitelli
  • Special Issue
  • - Volume 2015
  • - Article ID 605478
  • - Review Article

Clinical Development of Immune Checkpoint Inhibitors

Ayumu Ito | Shunsuke Kondo | ... | Shigehisa Kitano
  • Special Issue
  • - Volume 2015
  • - Article ID 869547
  • - Review Article

“Adherent” versus Other Isolation Strategies for Expanding Purified, Potent, and Activated Human NK Cells for Cancer Immunotherapy

Senthamil R. Selvan | John P. Dowling
  • Special Issue
  • - Volume 2015
  • - Article ID 261620
  • - Review Article

Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Immunosuppressive Microenvironment

Qiujun Guo | Jie Li | Hongsheng Lin
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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