BioMed Research International

Familial Parkinson’s Disease/Parkinsonism


Status
Published

1Department of Neurology / Department of Neuroscience for Neurodegenerative Disorders, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo 113-8421, Japan

2Department of Neurology, Seoul National University, Seoul, Republic of Korea

3National Neuroscience Institute, Singapore

4INSERM, Paris, France


Familial Parkinson’s Disease/Parkinsonism

Description

Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterised by parkinsonism (bradykinesia, resting tremor, rigidity, and postural instability) with good response to L-dopa. Although the majority of PD cases are sporadic, it is now clear that genetic factors contribute to the pathogenesis of PD. Indeed, PARK 1-18 loci have been identified in typical and atypical parkinsonism. Knowledge and understanding of these conditions have led to the development of animal models, successful therapies, and novel tools to characterize these clinical conditions and provide better care to patients.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular pathology underlying parkinsonism, the development of strategies to treat these conditions, and the evaluation of outcomes. We are particularly interested in articles describing the new modalities for clinical characterization of PD / parkinsonism and advances in molecular genetics and molecular diagnostics. Potential topics include, but are not limited to:

  • Advances in genetic findings of each locus or causative gene for PD / parkinsonism (PARK1-18: SNCA, Parkin, UCH-L1, PINK1, DJ-1, LRRK2, ATP13A2, HtrA2/Omi, PLA2G6, FBXO7, VPS35, and EIF4G1; SCA2, DCTN1, ....)
  • Known genetic risk factors for PD / parkinsonism (GBA, LRRK2, ..)
  • Interaction between genetic and environmental factors in PD / parkinsonism
  • Latest technologies for genetic testing, clinical evaluation, and measuring outcomes
  • Role of each molecule
  • Findings about disease mechanism and pathogenesis
  • Genetic testing and therapeutic strategy for PD / parkinsonism

Before submission authors should carefully read over the journal's Author Guidelines which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/neuroscience/fpdp/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 736915
  • - Editorial

Familial Parkinson’s Disease/Parkinsonism

Hiroyuki Tomiyama | Suzanne Lesage | ... | Beom S. Jeon
  • Special Issue
  • - Volume 2015
  • - Article ID 135674
  • - Research Article

SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson’s Disease in Chinese and Australians

Yue Huang | Gang Wang | ... | Glenda Halliday
  • Special Issue
  • - Volume 2015
  • - Article ID 172018
  • - Review Article

Could α-Synuclein Amyloid-Like Aggregates Trigger a Prionic Neuronal Invasion?

Maria Antònia Busquets | Alba Espargaró | ... | Raimon Sabate
  • Special Issue
  • - Volume 2015
  • - Article ID 125273
  • - Review Article

Parkinsonism in Spinocerebellar Ataxia

Hyeyoung Park | Han-Joon Kim | Beom S. Jeon
  • Special Issue
  • - Volume 2014
  • - Article ID 289728
  • - Review Article

Synaptojanin 1 Mutation in Parkinson’s Disease Brings Further Insight into the Neuropathological Mechanisms

Valérie Drouet | Suzanne Lesage
  • Special Issue
  • - Volume 2014
  • - Article ID 867321
  • - Research Article

LRRK2 G2385R and R1628P Mutations Are Associated with an Increased Risk of Parkinson’s Disease in the Malaysian Population

Aroma Agape Gopalai | Shen-Yang Lim | ... | Azlina Ahmad-Annuar
  • Special Issue
  • - Volume 2014
  • - Article ID 371256
  • - Review Article

Mutations in the ATP13A2 Gene and Parkinsonism: A Preliminary Review

Xinglong Yang | Yanming Xu
  • Special Issue
  • - Volume 2014
  • - Article ID 690796
  • - Review Article

Alternative Splicing Generates Different Parkin Protein Isoforms: Evidences in Human, Rat, and Mouse Brain

Soraya Scuderi | Valentina La Cognata | ... | Velia D'Agata
  • Special Issue
  • - Volume 2014
  • - Article ID 718732
  • - Research Article

Involvement of Endocytosis and Alternative Splicing in the Formation of the Pathological Process in the Early Stages of Parkinson’s Disease

Anelya Kh. Alieva | Maria I. Shadrina | ... | Petr A. Slominsky
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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