BioMed Research International

Specialized Bioactive Microbial Metabolites: From Gene to Product


Status
Published

1University of Insubria Varese, Como, Italy

2Fundación MEDINA, Granada, Spain

3Ivan Franko National University of Lviv, Lviv, Ukraine

4Tel Aviv University, Tel Aviv, Israel


Specialized Bioactive Microbial Metabolites: From Gene to Product

Description

A wealth of microbial gene clusters that encode novel biosynthetic pathways (or interesting variants of those already described) to bioactive microbial products, also known as secondary or specialized metabolites, are being unveiled with the ever increasing number of sequenced microbial genomes. These data confirm the primary role that some microbial groups such as actinomycetes, filamentous ascomycetes, cyanobacteria, and myxobacteria have had and might still continue to have in fulfilling pharmaceutical product pipelines and responding to unmet clinical needs. Whereas the difficulty to discover and develop in a reasonable time and acceptable cost new products from microbial sources has been widely recognized, recent advances in gene mining and heterologous expression, knowledge on regulatory networks, new analytical deconvolution, and chemical characterization tools are opening new avenues in the field of natural product discovery.

We invite authors to submit original research and review articles that address the understanding and eventually facing the current bottlenecks in the process of microbial product discovery and development. The invitation is directed to those investigators that are involved in classical and innovative microbial product screening projects, in chemical dereplication of microbial active extracts, in genome mining, in triggering cryptic gene clusters, in developing fermentation process and analytical tools, and in strain improvement of microbes producing interesting bioactive molecules as a result of their specialized (secondary) metabolic pathways.

Potential topics include, but are not limited to:

  • New resources for drug discovery including marine organisms, plant-associated microorganisms, and microorganisms from tropical forests
  • Genome mining: promises and limitations
  • Advantages and disadvantages of classical biological activity-guided microbial product screening
  • Novel strategies of microbial product screening
  • Chemical, biological, and bioinformatics tools for dereplication of active microbial extracts
  • Fermentation medium and process development
  • Classical strain improvement (mutagenesis and selection) versus DNA-based rational engineering
  • Tools and bottlenecks in homologous and heterologous expression of biosynthetic clusters
  • Analytical tools to assist strain and process development
  • Biological and chemical issues related to pharmaceutical guidelines’ compliance

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 276964
  • - Editorial

Specialized Bioactive Microbial Metabolites: From Gene to Product

Flavia Marinelli | Olga Genilloud | ... | Eliora Z. Ron
  • Special Issue
  • - Volume 2015
  • - Article ID 419383
  • - Research Article

A Novel Microbisporicin Producer Identified by Early Dereplication during Lantibiotic Screening

Lucia Carrano | Monica Abbondi | ... | Flavia Marinelli
  • Special Issue
  • - Volume 2015
  • - Article ID 835761
  • - Review Article

Biologically Active Metabolites Synthesized by Microalgae

Michele Greque de Morais | Bruna da Silva Vaz | ... | Jorge Alberto Vieira Costa
  • Special Issue
  • - Volume 2015
  • - Article ID 465056
  • - Review Article

Violacein: Properties and Production of a Versatile Bacterial Pigment

Seong Yeol Choi | Kyoung-hye Yoon | ... | Robert J. Mitchell
  • Special Issue
  • - Volume 2015
  • - Article ID 687915
  • - Research Article

Improved Production of Sublancin 168 Biosynthesized by Bacillus subtilis 168 Using Chemometric Methodology and Statistical Experimental Designs

Shengyue Ji | Weili Li | ... | Binyun Cao
  • Special Issue
  • - Volume 2015
  • - Article ID 591349
  • - Review Article

Antibacterial Discovery and Development: From Gene to Product and Back

Victor Fedorenko | Olga Genilloud | ... | Eliora Z. Ron
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision77 days
Acceptance to publication53 days
CiteScore2.410
Impact Factor2.197
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