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Bioproduction, Biosynthesis, Analysis, and Biological Activities of Resveratrol and Derivatives

Call for Papers

Resveratrol represents the most famous compound of the phytostilbene family due to its positive effects on human health and its role as a phytoalexin in various plants. Firstly identified as a major actor of the French paradox related to its antioxidant properties, resveratrol has been reported to be an active molecule against cancer, cardiovascular and neurodegenerative diseases, diabetes, and inflammation and able to promote the longevity of different types of organisms. For these reasons, resveratrol is now widely used as a nutraceutical and in cosmetics. Moreover, namely, in grapevine, resveratrol is transformed in many other derivatives like monomers (piceid or pterostilbene) or oligomers, among them the so-called viniferins. These molecules also exhibit biological activities but their extraction especially from grape canes is difficult and not sustainable, limiting their study and their potential use. Plant biotechnology systems offer the possibility of producing secondary metabolites in axenic conditions and grapevine cell cultures have shown their potential to produce several g/L of resveratrol and viniferin-dimers in response to elicitors. More recently, hairy roots cultures have also been reported as valuable models to produce resveratrol monomers and more complex oligomers such as resveratrol trimers and tetramers, the polymerization mechanisms of which are not fully elucidated. In this context, plant biotechnology systems appear as valuable models for studying the biosynthesis, the transport, and the polymerization of the stilbene oligomers. Moreover, plant cells can be considered as factories useful for the production of numerous resveratrol derivatives in sufficient amounts and with sufficient purity to allow evaluation of their biological activity.

This special issue will be thus particularly dedicated to the study of resveratrol and its derivatives (monomers and oligomers) in relation to their production, extraction, purification, and identification from plant cell or plant organ systems as well as studies of their biosynthesis and their biological activities. All works including research papers and reviews related to these items will be considered for publication. The aim of this special issue is to cover all aspects of the biotechnological production of resveratrol and its derivatives from their extraction to the evaluation of their biological activity.

Potential topics include but are not limited to the following:

  • Plant cells and organ cultures for the production of phytostilbenes
  • Resveratrol derivatives
  • Biosynthesis of resveratrol and derivatives (monomers and oligomers)
  • Elicitation
  • Extraction and purification
  • Chemical analysis
  • Phytostilbenes and plant defense mechanisms
  • Biological activity including antifungal, antibacterial, anticancer, antioxidant activities and so on

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 29 June 2018
Publication DateNovember 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

Lead Guest Editor

  • Eric Courot, Université de Reims Champagne-Ardenne, Reims, France

Guest Editors