Table of Contents Author Guidelines Submit a Manuscript

Normal and Pathological Placental Angiogenesis

Call for Papers

Placental angiogenesis is a pivotal process that establishes fetomaternal circulation, ensures efficient maternofetal exchange, plays a key mechanistic role in the elaboration of the placental villous tree, and contributes to the overall development of the placenta throughout pregnancy. Failure in these processes is tightly linked to the development of placental pathologies such as preeclampsia (PE), early pregnancy loss, and intrauterine growth restriction (IUGR). It is now well established that a close relationship exists between embryonic development and the degree of placental angiogenesis. A key discovery in the investigation on placental pathologies was the understanding that major phenotypes of PE are associated with dysregulations in antiangiogenic factors. To date, numerous insults such as maternal chemical dependency including tobacco smoke, metal element toxicity, tumorigenesis, and oxidative stress have been shown to influence pregnancy outcome by directly affecting placental angiogenesis. In the last decade, compelling advances highlighted the central role of mesenchymal stem cells/multipotent stromal cells in placental angiogenesis and brought new insights into the understanding of the fine mechanisms underlying placental angiogenesis. Also, we know now how to measure the processes of placental angiogenesis, thanks to the innovative methods developed by specialized groups in the field of placentology.

We particularly take an interest in manuscripts that report relevance of factors that regulate angiogenesis to improve prognosis, monitoring, and therapy of placental pathologies. Reviews that summarize one or different aspects around placental angiogenesis are welcome. Furthermore, papers dealing with criteria for optimal PA measurement for clinical guidance would be of great interest. Potential topics include, but are not limited to:

  • Placental angiogenesis and reproductive medicine
  • Molecular aspects of placental angiogenesis
  • Investigation of placental angiogenesis: Methods of measurement
  • Angiogenesis in tumour in the placenta
  • Metal elements in the control of placental angiogenesis
  • Smoking and placental angiogenesis
  • Influence of oxidative stress on placental angiogenesis
  • Trophoblast–derived angiogenic factors in normal and placental pathologies
  • Role of mesenchymal stem cells/multipotent stromal cells in placental angiogenesis
  • Circulating angiogenic molecules as clinical biomarkers in the predictions of pregnancy complications

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:

Manuscript DueFriday, 11 July 2014
First Round of ReviewsFriday, 3 October 2014
Publication DateFriday, 28 November 2014

Lead Guest Editor

  • Nadia Alfaidy, Inserm U1036, Institute of Life Sciences Research and Technologies, University Joseph Fourier Grenoble and Department of Medical Biochemistry, Grenoble, France

Guest Editors

  • Padma Murthi, Deptartment of Obstetrics and Gynaecology (RWH), University of Melbourne, Parkville, VIC 3052, Australia
  • Nathalie Bardin, Inserm UMR–S 1076, Faculté de Pharmacie, Aix–Marseille University, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France