BioMed Research International

Addressing Peritoneal Dialysis: In vitro PD Models, in vivo Rodent PD Model, Clinical Biobanks, and Underutilization of PD


Status
Published

Lead Editor

1VU University Medical Center, Amsterdam, Netherlands

2Cardiff University, Cardiff, UK

3Baxter World Trade, Lessines, Belgium

4Poznan University of Medical Science, Poznań, Poland


Addressing Peritoneal Dialysis: In vitro PD Models, in vivo Rodent PD Model, Clinical Biobanks, and Underutilization of PD

Description

Renal replacement therapy (RRT) is necessary for the survival of patients with end-stage renal disease (ESRD) both prior to kidney transplantation and in patients where kidney transplantation is not available. Peritoneal dialysis (PD) and hemodialysis (HD) are lifesaving RRTs for more than 2 million patients with ESRD worldwide. As the incidence of chronic renal disease has doubled over the past decade the number of patients with ESRD is expected to increase 5-8% annually. Although long-term morbidity and mortality are comparable between PD and HD, there are an early patient survival advantages for PD and a better quality of life. Moreover, PD is cost-effective as compared to hospital-based HD. Nevertheless, only one out of 10 patients is treated with PD, which suggests a general underutilization. PD is a simple therapy in which PD fluid is exchanged several times a day; the major limitations are peritoneal membrane damage on the long term and infection. PD could be largely enhanced if one can identify diagnostic and therapeutic tools to improve PD outcome that promote function of the peritoneal membrane and prevent infectious complications.

Therefore we invite investigators to contribute original research articles and reviews that stimulate to understand the basic cell culture based research, that mimics the clinical situation in a relevant rodent PD model, that describes the outcome of clinical studies using new biomarkers or describes new interventions, and moreover contributes to the awareness of the different use of PD in countries all over the world.

Potential topics include, but are not limited to:

  • Recent developments in in vitro research with key cell players like mesothelial cells, fibroblasts, macrophages, and lymphocytes
  • Recent development with respect to proteomics
  • Recent uremic PD models mimicking the clinical situation
  • Recent interventions in these models improving the PD-induced changes
  • Validation of new biomarkers in clinical trials
  • New interventions in patients and personalized medicine
  • Describing reasons for large discrepancies in PD use worldwide
  • Going into complications of comorbidity as cardiovascular changes

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 4964316
  • - Editorial

Addressing Peritoneal Dialysis: In Vitro PD Models, In Vivo Rodent PD Model, Clinical Biobanks, and Underutilization of PD

Robert H. J. Beelen | Donald J. Fraser | ... | Janusz Witowski
  • Special Issue
  • - Volume 2015
  • - Article ID 241098
  • - Clinical Study

Effluent Tenascin-C Levels Reflect Peritoneal Deterioration in Peritoneal Dialysis: MAJOR IN PD Study

Ichiro Hirahara | Eiji Kusano | ... | Daisuke Nagata
  • Special Issue
  • - Volume 2015
  • - Article ID 989560
  • - Research Article

Rapamycin Protects from Type-I Peritoneal Membrane Failure Inhibiting the Angiogenesis, Lymphangiogenesis, and Endo-MT

Guadalupe Tirma González-Mateo | Anna Rita Aguirre | ... | Georgios Liappas
  • Special Issue
  • - Volume 2015
  • - Article ID 431092
  • - Review Article

Overcoming the Underutilisation of Peritoneal Dialysis

Jernej Pajek
  • Special Issue
  • - Volume 2015
  • - Article ID 382652
  • - Research Article

Senescence-Associated Changes in Proteome and O-GlcNAcylation Pattern in Human Peritoneal Mesothelial Cells

Rebecca Herzog | Silvia Tarantino | ... | Janusz Witowski
  • Special Issue
  • - Volume 2015
  • - Article ID 468574
  • - Research Article

Protective Effects of Paricalcitol on Peritoneal Remodeling during Peritoneal Dialysis

Andrea W. D. Stavenuiter | Karima Farhat | ... | Marc G. Vervloet
  • Special Issue
  • - Volume 2015
  • - Article ID 106902
  • - Research Article

A Novel Mouse Model of Peritoneal Dialysis: Combination of Uraemia and Long-Term Exposure to PD Fluid

E. Ferrantelli | G. Liappas | ... | R. H. J. Beelen
  • Special Issue
  • - Volume 2015
  • - Article ID 427038
  • - Review Article

Regulation of Synthesis and Roles of Hyaluronan in Peritoneal Dialysis

Timothy Bowen | Soma Meran | ... | Thomas Sitter
  • Special Issue
  • - Volume 2015
  • - Article ID 929806
  • - Review Article

microRNA Regulation of Peritoneal Cavity Homeostasis in Peritoneal Dialysis

Melisa Lopez-Anton | Timothy Bowen | Robert H. Jenkins
  • Special Issue
  • - Volume 2015
  • - Article ID 595030
  • - Research Article

Vitamin D Can Ameliorate Chlorhexidine Gluconate-Induced Peritoneal Fibrosis and Functional Deterioration through the Inhibition of Epithelial-to-Mesenchymal Transition of Mesothelial Cells

Yi-Che Lee | Shih-Yuan Hung | ... | Yuan-Yow Chiou
BioMed Research International
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Acceptance rate31%
Submission to final decision67 days
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CiteScore3.600
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