BioMed Research International

Innovative Pharmacological/Therapeutic Approaches against Hepatic Ischemia/Reperfusion Injury


Status
Published

1Pharmacology and Toxicology Unit, Pavia, Italy

2University of Kansas Medical Center, Kansas City, USA

3Abdominale Transplantatiechirurgie en –coördinatie, Leuven, Belgium

4University of Florida, Gainesville, USA


Innovative Pharmacological/Therapeutic Approaches against Hepatic Ischemia/Reperfusion Injury

Description

Prolonged oxygen deprivation corresponding to the ischemic period is observed during liver resection, transplantation, and trauma and subsequent oxygen restoration always leads to reperfusion injury. In particular, the ischemic period represents an inevitable event during conventional organ preservation before transplantation and the magnitude and severity of reperfusion injury depend on the time of liver preservation. Faced with the increasing shortage of donor organs for transplantation, there is renewed interest in marginal livers, such as those obtained from non-heart-beating donors (NHBDs) or fatty livers, particularly susceptible to ischemia/reperfusion injury.

Articles published in this issue not only help to identify new pharmacological approaches for improving liver function during ischemia/reperfusion damage, but will also stimulate the identification of molecular mediators of hepatic injury.

This special issue will become an international forum for researchers to summarize the most recent therapeutics strategies against hepatic I/R injuries.

Potential topics include, but are not limited to:

  • Redox-modulating therapies
  • Anti-inflammatory therapies
  • Therapeutic antibodies and small molecules
  • Gene therapies
  • Preservation techniques
  • Preconditioning
  • Donor treatment

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 918583
  • - Editorial

Innovative Pharmacological/Therapeutic Approaches against Hepatic Ischemia/Reperfusion Injury

Mariapia Vairetti | Hartmut Jaeschke | ... | Andrea Ferrigno
  • Special Issue
  • - Volume 2015
  • - Article ID 183469
  • - Review Article

Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury

Kristina L. Go | Sooyeon Lee | ... | Jae-Sung Kim
  • Special Issue
  • - Volume 2015
  • - Article ID 794287
  • - Research Article

Protective Effect of Intravenous High Molecular Weight Polyethylene Glycol on Fatty Liver Preservation

Mohamed Bejaoui | Eirini Pantazi | ... | Joan Roselló-Catafau
  • Special Issue
  • - Volume 2015
  • - Article ID 286746
  • - Review Article

Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype

Elisa Alchera | Chiara Imarisio | ... | Rita Carini
  • Special Issue
  • - Volume 2015
  • - Article ID 635041
  • - Research Article

Comparative Study on the Cytoprotective Effects of Activated Protein C Treatment in Nonsteatotic and Steatotic Livers under Ischemia-Reperfusion Injury

Akitoshi Matsuda | Naohisa Kuriyama | ... | Shuji Isaji
  • Special Issue
  • - Volume 2015
  • - Article ID 894679
  • - Research Article

PPARα Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury

Eirini Pantazi | Emma Folch-Puy | ... | Joan Roselló-Catafau
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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