BioMed Research International

Applications of Synthetic Biology in Microbial Biotechnology


Publishing date
15 Apr 2010
Status
Published
Submission deadline
15 Oct 2009

Lead Editor

1Department of Chemical Engineering, The University of Texas at Austin, 1 University Station C0400, Austin, TX 78712, USA

2Department of Chemical Engineering, Pennsylvania State University, 226A Fenske Laboratory, University Park, PA 16802, USA

3Department of Molecular Microbiology and Laboratory of Molecular Cell Biology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, 3001 Leuven-Heverlee, Belgium

4Department of Chemical Engineering, University of Maryland at College Park, 1208D Chemical and Nuclear Engineering Building, College Park, MD 20742, USA


Applications of Synthetic Biology in Microbial Biotechnology

Description

Recent advances in synthetic biology have greatly expanded the capacity to improve pathway performance and cellular phenotype. The design, use, and importation of constructed genetic control elements, optimized genes, and functional genetic circuits can be used to modulate the function metabolic pathways. The modularity and hierarchy of parts, devices, systems, and chassis provide a framework for studying and controlling the cell. Moreover, synthetic biology provides an interface at which protein engineering, directed evolution, DNA synthesis, and in silico design can direct the field of metabolic engineering.

We invite the authors to present original research articles as well as review articles that will help to define the role that synthetic biology approaches will have in microbial biotechnology and metabolic engineering. Specifically, the topics to be considered include, but are not limited to:

  • Application of synthetic regulatory elements to control metabolism
  • Use of DNA synthesis/construction as a tool for pathway assembly
  • Creation of novel genetic control elements for fine-tuned expression
  • Use of RNA-based logic circuits for cellular regulation
  • Use of gene circuits to regulate cellular function
  • Application of RNA or protein modifications to modulate enzyme activity
  • Synthetic applications of codon optimization for improved metabolic pathways
  • de novo design and synthesis of enzymes, pathways, and phenotypes
  • Understanding and quantifying pathways toward obtaining insights on pathway synthesis
  • Construction of integrated genetic networks with dynamic responses
  • Engineering cells through alterations of regulatory and transcriptional machinery

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jbb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 918391
  • - Editorial

Applications of Synthetic Biology in Microbial Biotechnology

Hal Alper | Patrick Cirino | ... | Ganesh Sriram
  • Special Issue
  • - Volume 2010
  • - Article ID 232016
  • - Review Article

Biology by Design: From Top to Bottom and Back

Brian R. Fritz | Laura E. Timmerman | ... | Michael C. Jewett
  • Special Issue
  • - Volume 2010
  • - Article ID 541698
  • - Review Article

Synthetic Biology Guides Biofuel Production

Michael R. Connor | Shota Atsumi
  • Special Issue
  • - Volume 2010
  • - Article ID 541609
  • - Review Article

Mathematical Modeling: Bridging the Gap between Concept and Realization in Synthetic Biology

Yuting Zheng | Ganesh Sriram
  • Special Issue
  • - Volume 2010
  • - Article ID 761042
  • - Review Article

Metabolic Engineering for Production of Biorenewable Fuels and Chemicals: Contributions of Synthetic Biology

Laura R. Jarboe | Xueli Zhang | ... | Lonnie O. Ingram
  • Special Issue
  • - Volume 2010
  • - Article ID 130781
  • - Review Article

Synthetic Biology: Tools to Design, Build, and Optimize Cellular Processes

Eric Young | Hal Alper
  • Special Issue
  • - Volume 2010
  • - Article ID 459760
  • - Review Article

Toward Engineering Synthetic Microbial Metabolism

George H. McArthur | Stephen S. Fong
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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