BioMed Research International

Molecular Mechanism of Muscle Contraction: New Perspectives and Ideas


Publishing date
09 Jan 2015
Status
Published
Submission deadline
22 Aug 2014

1McGill University, Montreal, Canada

2University of Miami, Coral Gables, USA

3University of Liverpool, Liverpool, UK


Molecular Mechanism of Muscle Contraction: New Perspectives and Ideas

Description

Movement, contraction, and cell motility are the basic phenomena of life underlying various physiological and pathological processes. Muscles, the specialized structures capable of transforming chemical energy stored in the form of ATP into mechanical work, are instrumental in generating motility and force to support many essential body functions in animals and humans.

Biological motility and its particular case, muscle contraction, are based on the cyclic interactions of the myosin heads with actin filaments and their binding proteins that in concert regulate the organization and properties of the contractile systems. Properties and composition of the contractile proteins vary between systems and this variability determines the structural and functional properties of the systems and how they differ from each other. Therefore, one of the major questions of muscle motility is to be able to understand not only the composition and the properties of contractile proteins but also the physiological and structural features of muscle cells where they are synthesized.

We invite investigators to contribute to the original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular mechanisms underlying muscle contraction in different organisms from molluscs to humans. We are interested in the manuscripts describing new ideas and approaches for studying the regulation of actin and its interaction with myosin in all types of muscle and in particular in those focusing on new insights into the unique phenomena known as latch and catch states in smooth muscles.

Potential topics include, but are not limited to:

  • Recent findings in the field of muscle regulation
  • New insights into mechanisms of latch and catch states
  • Giant proteins in muscle
  • Force sensing mechanisms in muscle
  • Power stroke of muscle contraction
  • Myosin motors in vitro and in cells
  • Molecular machines and how they function inside cells
  • Actin and actin-binding proteins
  • Thin-filament regulatory systems
  • Myosin and the thick filament proteins
  • Structural and functional aspects of myosin phosphorylation
  • Cell mechanics and motility
  • Cytoskeletal protein dynamics

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 694345
  • - Editorial

Molecular Mechanism of Muscle Contraction: New Perspectives and Ideas

Oleg S. Matusovsky | Olga Mayans | Danuta Szczesna-Cordary
  • Special Issue
  • - Volume 2015
  • - Article ID 816019
  • - Research Article

A Kinase Anchoring Protein 9 Is a Novel Myosin VI Binding Partner That Links Myosin VI with the PKA Pathway in Myogenic Cells

Justyna Karolczak | Magdalena Sobczak | ... | Maria Jolanta Rędowicz
  • Special Issue
  • - Volume 2015
  • - Article ID 273936
  • - Research Article

Induction of Ankrd1 in Dilated Cardiomyopathy Correlates with the Heart Failure Progression

Julius Bogomolovas | Kathrin Brohm | ... | Siegfried Labeit
  • Special Issue
  • - Volume 2015
  • - Article ID 245154
  • - Review Article

Poorly Understood Aspects of Striated Muscle Contraction

Alf Månsson | Dilson Rassier | Georgios Tsiavaliaris
  • Special Issue
  • - Volume 2015
  • - Article ID 742536
  • - Research Article

The R21C Mutation in Cardiac Troponin I Imposes Differences in Contractile Force Generation between the Left and Right Ventricles of Knock-In Mice

Jingsheng Liang | Katarzyna Kazmierczak | ... | Danuta Szczesna-Cordary
  • Special Issue
  • - Volume 2015
  • - Article ID 468548
  • - Research Article

Dissociation of Calcium Transients and Force Development following a Change in Stimulation Frequency in Isolated Rabbit Myocardium

Kaylan M. Haizlip | Nima Milani-Nejad | ... | Paul M. L. Janssen
  • Special Issue
  • - Volume 2015
  • - Article ID 396593
  • - Research Article

Low Frequency Electromagnetic Field Conditioning Protects against I/R Injury and Contractile Dysfunction in the Isolated Rat Heart

Dariusz Bialy | Magdalena Wawrzynska | ... | Grzegorz Sawicki
  • Special Issue
  • - Volume 2015
  • - Article ID 714197
  • - Review Article

The Sarcomeric M-Region: A Molecular Command Center for Diverse Cellular Processes

Li-Yen R. Hu | Maegen A. Ackermann | Aikaterini Kontrogianni-Konstantopoulos
  • Special Issue
  • - Volume 2014
  • - Article ID 810371
  • - Research Article

Inhibition of MMP-2 Expression with siRNA Increases Baseline Cardiomyocyte Contractility and Protects against Simulated Ischemic Reperfusion Injury

Han-Bin Lin | Virgilio J. J. Cadete | ... | Grzegorz Sawicki
BioMed Research International
 Journal metrics
Acceptance rate30%
Submission to final decision66 days
Acceptance to publication31 days
CiteScore3.600
Impact Factor2.276
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