BioMed Research International

Bioactive Materials for Bone Tissue Engineering


Status
Published

1Consiglio Nazionale delle Ricerche, Rome, Italy

2University Politehnica of Bucharest, Bucharest, Romania

3King's College London, London, UK

4Ceramic Science and Technology, Faenza, Italy

5Russian Academy of Sciences, Moscow, Russia


Bioactive Materials for Bone Tissue Engineering

Description

For early biomaterials, they were required to have a combination of physicochemical properties, suitable to replace human body tissues and to be biologically inert. Since then a long way has been brought to the third generation biomaterials, whose role is to be both resorbable and bioactive, i.e., to be able to elicit a controlled action in physiological conditions. Recently, the advances in cellular proteomics and genomics paved the way to the fourth generation of biomaterials, i.e., biomimetic and smart materials, and to their application in regenerative nanomedicine.

There is a wide range of materials used for orthopedics and dentistry, from metals, alloys, ceramics, and polymers to bioactive glass systems and hybrid composites. Among them, calcium phosphates based and bioactive glass materials have attracted a significant attention and are widely used in bone tissue engineering. In particular, calcium phosphates are more traditional for bone graft substitution, since their composition is close to the mineral part of the bone tissue. However, their performances could still be improved. Concerning bioactive glasses, the focus point is their ability to continuously exchange ions with physiological liquids, releasing appropriate trace elements in order to stimulate specific cellular response, aimed to activate genes responsible for osteogenesis and bone tissue regeneration.

This issue is focused on the new frontiers in research studies dedicated to bioactive materials in the form of scaffolds, coatings, cements, etc. for biomedical applications and related clinical investigations. Based on the requirements of the modern biomedical technology, the novel research strategies in biomaterials field are nowadays directed towards biomaterials endowed with piezoelectricity, radioopacity, mechanical resistance, proper porosity, and characteristics suitable for drug delivery and for the controlled release of active principles. Apart from microstructure and composition characteristics, a special stress should be given to the host tissue/material interface. Both experimental and theoretical papers are welcome.

Potential topics include, but are not limited to:

  • Synthesis and characterisation of bioactive material systems, including powders, granules, scaffolds, films, injectable cements, foams, gels, etc.
  • Theoretical simulations and modelling of bioactive materials
  • Fabrication and processing
  • Material-protein adsorption and material-cell interactions
  • Clinical applications

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 3741428
  • - Editorial

Bioactive Materials for Bone Tissue Engineering

Julietta V. Rau | Iulian Antoniac | ... | Antonio Ravaglioli
  • Special Issue
  • - Volume 2016
  • - Article ID 7078989
  • - Research Article

An In Vitro Comparison of PMMA and Calcium Sulfate as Carriers for the Local Delivery of Gallium(III) Nitrate to Staphylococcal Infected Surgical Sites

Rebecca A. Garcia | David J. Tennent | ... | Carlos J. Sanchez
  • Special Issue
  • - Volume 2015
  • - Article ID 575079
  • - Research Article

Long-Term In Vitro Degradation of a High-Strength Brushite Cement in Water, PBS, and Serum Solution

Ingrid Ajaxon | Caroline Öhman | Cecilia Persson
  • Special Issue
  • - Volume 2015
  • - Article ID 705871
  • - Research Article

Photocatalytical Antibacterial Activity of Mixed-Phase TiO2 Nanocomposite Thin Films against Aggregatibacter actinomycetemcomitans

Sinem Yeniyol | Ilven Mutlu | ... | John Lawrence Ricci
  • Special Issue
  • - Volume 2015
  • - Article ID 261938
  • - Research Article

Bone Regeneration by Nanohydroxyapatite/Chitosan/Poly(lactide-co-glycolide) Scaffolds Seeded with Human Umbilical Cord Mesenchymal Stem Cells in the Calvarial Defects of the Nude Mice

Fei Wang | Xiao-Xia Su | ... | Xin-Qin Si
  • Special Issue
  • - Volume 2015
  • - Article ID 323571
  • - Research Article

In Vitro Behavior of Human Adipose Tissue-Derived Stem Cells on Poly(ε-caprolactone) Film for Bone Tissue Engineering Applications

Cecilia Romagnoli | Roberto Zonefrati | ... | Maria Luisa Brandi
  • Special Issue
  • - Volume 2015
  • - Article ID 253858
  • - Research Article

Effects of P-15 Peptide Coated Hydroxyapatite on Tibial Defect Repair In Vivo in Normal and Osteoporotic Rats

Rasmus Hestehave Pedersen | Marina Rasmussen | ... | Ming Ding
  • Special Issue
  • - Volume 2015
  • - Article ID 684826
  • - Review Article

Clinical Applications of S53P4 Bioactive Glass in Bone Healing and Osteomyelitic Treatment: A Literature Review

N. A. P. van Gestel | J. Geurts | ... | J. J. Arts
  • Special Issue
  • - Volume 2015
  • - Article ID 459393
  • - Research Article

Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study

Nam-Ho Kim | So-Hyoun Lee | ... | Jung-Bo Huh
  • Special Issue
  • - Volume 2015
  • - Article ID 134093
  • - Review Article

Titanium-Based Hip Stems with Drug Delivery Functionality through Additive Manufacturing

Martin B. Bezuidenhout | Dimitar M. Dimitrov | ... | Leon M. T. Dicks
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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