BioMed Research International

Tissue Engineering in Gene and Cell Therapies for Neurological Disorders


Publishing date
27 Nov 2015
Status
Published
Submission deadline
14 Aug 2015

Lead Editor

1Sun Yat-sen University, Guangdong, China

2University of Kansas Medical Center, Kansas City, USA

3Peking University, Beijing, China

4Harvard Medical School, Boston, USA

5Karolinska Hospital, Stockholm, Sweden


Tissue Engineering in Gene and Cell Therapies for Neurological Disorders

Description

With the development of neural tissue engineering, the therapeutic outcomes of gene and cell therapies were now constantly augmenting for some neurological disorders. Gene and cell therapies have a high potentiality to be an ultimate therapeutical strategy for clinical treatment of most neurological disorders, especially those neurodegenerative diseases. However, the potential applications and mechanisms for such treatments are still poorly comprehended and are still the research focus of neuroscience. Knowledge and understanding of the advantages of the combination of neural tissue engineering with gene and cell therapies will lead to the development of novel tools and successful therapies to neurological illnesses.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to explore the application of tissue engineering in gene and cell therapies for neurological disorders. For further clinical usage in neurological disorders, we are particularly interested in articles describing new and novel gene vectors as well as ideal routes of administration; application of biocompatible biomaterials for gene delivery system and cell-carriers; effects of microenvironment on gene expression and cell transplantation; imaging techniques for tracking transplanted gene and cells.

Potential topics include, but are not limited to:

  • Development of highly efficient gene expression and delivery system including viral and nonviral gene vectors for tissue repair in the nervous system
  • Exploration and evaluation of the efficiency of new ideal routes of administration of gene and cells into brain
  • Evaluation of appropriate biomaterials in terms of biocompatibility and biodegradability, biomechanical competency, and functionalization with instructive cues to guide neuroregeneration
  • Tissue engineering which integrates cell therapies and scaffolding technologies to replace damaged neurons and to reestablish the coaxial connection of neuronal circuits for functional recovery
  • Assessment of the safety and toxic side effects with gene and cell therapies
  • Latest technologies of noninvasive in vivo imaging to track the transplanted gene or cells

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 8738504
  • - Editorial

Tissue Engineering in Gene and Cell Therapies for Neurological Disorders

Jun Liu | William Z. Suo | ... | Gongxiong Wu
  • Special Issue
  • - Volume 2015
  • - Article ID 131054
  • - Research Article

In Vivo Targeted Magnetic Resonance Imaging of Endogenous Neural Stem Cells in the Adult Rodent Brain

Xiao-Mei Zhong | Fang Zhang | ... | Jun Shen
  • Special Issue
  • - Volume 2015
  • - Article ID 610281
  • - Research Article

Screening and Identification of ssDNA Aptamer for Human GP73

Jingchun Du | Jianming Hong | ... | Xia Xu
  • Special Issue
  • - Volume 2015
  • - Article ID 161020
  • - Research Article

PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy

Shengnuo Fan | Bei Zhang | ... | Jun Liu
  • Special Issue
  • - Volume 2015
  • - Article ID 817914
  • - Research Article

Effects of Nogo-A Silencing on TNF-α and IL-6 Secretion and TH Downregulation in Lipopolysaccharide-Stimulated PC12 Cells

Jianbin Zhong | Shengnuo Fan | ... | Jun Liu
  • Special Issue
  • - Volume 2015
  • - Article ID 895284
  • - Research Article

Calreticulin Binds to Fas Ligand and Inhibits Neuronal Cell Apoptosis Induced by Ischemia-Reperfusion Injury

Beilei Chen | Zhengzheng Wu | ... | Yun Xu
  • Special Issue
  • - Volume 2015
  • - Article ID 857202
  • - Research Article

Overexpression of NTRK1 Promotes Differentiation of Neural Stem Cells into Cholinergic Neurons

Limin Wang | Feng He | ... | Zhonglin Liu
BioMed Research International
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Acceptance rate31%
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