Malaria remains a complex disease affecting over 200 million people and causing over 400,000 deaths globally in 2018. Malaria has existed for many years yet defies multi-targeted control strategies aimed at reducing the disease burden. Eliminating and eradicating malaria has been slowly achieved in some regions, but recently, increasing parasite resistance to therapies has stalled this progress in many other regions, especially in South East Asia and Africa.

Sequencing data and genomic tools provide great insights into malaria parasite genetic diversities and disease dynamics, hence improving knowledge of its elusive strategies. As the development of drug resistance by the parasite limits the efficacy of antimalarial therapies, genomic and genetic tools identifying new phenotypes and the implications for malaria control efforts are important. To achieve global eradication and elimination of malaria, elucidating the evolving mechanisms of malarial parasite biology and antimalarial mechanisms will give further understanding of the disease, which is integral for future control. Translating these findings to effectively eliminate and eradicate malaria globally will go a long way to reduce human suffering.

In this Special Issue, we seek articles investigating new molecular pathways for parasite survival, molecular signatures of artemisinin resistance, mechanisms of antimalarial drugs, and new technologies for malaria control. Submissions relating to genetic modifications of Plasmodium falciparum, Plasmodium vivax, stage dynamics of infections, gametocytaemia, antimalarial chemotherapy, and current topics in malaria control are welcome. This Special Issue aims to attract limited review articles on state-of-the-art molecular tools for mapping transmission trends and antimalarial resistance.

Potential topics include but are not limited to the following:

• Genomic surveillance for malaria elimination and eradication
• New mechanisms of parasite resistance to antimalarial drugs
• Vector resistance and control
• Genetic diversities and heterogeneity of infections
• Malaria vaccine efficacy
• Molecular mechanisms of malaria pathogenesis