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Recent Trends in Pharmaceutical Radiochemistry for Molecular PET Imaging

Call for Papers

In the field of radiopharmaceutical research, the development of new radiochemistry methods has been one of the major driving forces for positron emission tomography (PET) imaging during the past decade. The use and availability of the positron emitters C-11, F-18, Ga-68, Cu-64, or Zr-89, to name a few, have enormously increased and especially in terms of chemoselectivity and radiolabeling efficacy significant progress have been made. In the field of F-18 chemistry, various click chemistry-based labeling methods, the use of the silicon-fluoride acceptor reagents, and Al-F-NOTA complexes offer an even more simplified strategy to introduce F-18 into biomolecules. These techniques facilitate the radiosyntheses of tracers and thus accelerate their pronounced use in preclinical studies and even clinical trials. A similar situation is seen in the field of metallic positron emitters, where additional strategies have been developed to extend and to improve the radiometal chemistry, for example, by optimizing the stability of the metal complexes.

We invite young scientists and principle investigators to contribute original research articles as well as review articles that present modern techniques in pharmaceutical radiochemistry. The content of the articles should focus on the PET imaging application of the newly developed tracers, not solely containing chemistry. Review articles should focus on a summary of the current status, reflecting the literature of the last 6 years only.

We are interested in original as well as review articles that represent the current role of pharmaceutical radiochemistry in facilitating molecular imaging by PET. Potential topics include, but are not limited to:

  • Click chemistry-driven tracer development
  • Chemoselective radiolabeling methods
  • Radiometal chemistry: chelators and coordination chemistry
  • Radiometal chemistry: current status and recent developments (e.g., Zr-89, Y-86, Nb-90, Sc-44, etc)
  • Tracer development by using the AlF-chemistry
  • C-11 labeling chemistry and its application in neuroimaging by PET
  • Novel 18F-labeled prosthetic groups and their use in tracer development.

Before submission authors should carefully read over the journal’s Author Guidelines which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:

Manuscript DueFriday, 28 February 2014
First Round of ReviewsFriday, 23 May 2014
Publication DateFriday, 18 July 2014

Lead Guest Editor

  • Olaf Prante, Department of Nuclear Medicine, Molecular Imaging and Radiochemistry, Friedrich-Alexander University (FAU), Erlangen, Germany

Guest Editors

  • Roland Haubner, Department of Nuclear Medicine, Medicinal University Innsbruck, Innsbruck, Austria
  • Patrick Riss, Department of Chemistry, University Oslo, Oslo, Norway