BioMed Research International

Simulations of Heart Function


Status
Published

1Federal University of Juiz de Fora, Juiz de Fora, Brazil

2Physikalisch-Technische Bundesanstalt, Braunschweig, Germany

3Rochester Institute of Technology, Rochester, USA

4Simula Research Laboratory, Fornebu, Norway


Simulations of Heart Function

Description

The heart is a robust and reliable organ, which, approximately once per second, pumps the blood to the whole body. This activity involves the fine coupling of numerous components, involving a large variety of physical processes and covering a wide range of scales. For instance, heart function depends on cell metabolism, electrophysiology, and mechanics; ion channels, ion concentrations, and gap junction distribution; material and electrical properties of cardiac tissue and the anatomical organization of this tissue in fibers and sheets; material properties and organization of heart vascular tree and their relation to cardiac perfusion. Understanding the details of these complex systems, as well as the interaction between them, is crucial for understanding heart function in health and disease.

This special issue focuses on cardiac modeling and simulations that can contribute to improving the understanding of this multifaceted system, under normal conditions or different cardiac pathologies. Multiple types of computational and mathematical models are being used to describe heart function at different levels of details. For instance, relatively simple models have been employed to characterize the main properties of action potential propagation and wave dynamics in cardiac tissue. Detailed physiological models have been employed to improve our understanding of arrhythmia generation, fibrillation, and defibrillation. Coupled models of cardiac electromechanics that involve multiple scales, from intracellular to whole organ, were developed to describe the relation between electric signals, such as the electrocardiogram and heart contraction. In summary, cardiac modeling has been developed over several decades to become a valuable tool for studying heart function.

We invite investigators to contribute original research articles as well as review articles on modeling of cardiac tissue.

Potential topics include, but are not limited to:

  • Basic theory of heart function: action potential wave propagation in cardiac tissue, cardiac contraction, cardiac metabolism, and perfusion
  • Models that couple different physics and scales, for example, models of electromechanical coupling
  • Relation between anatomy, microstructures, and heart function, for example, the impact of gap junction distribution and fibrosis on cardiac arrhythmia
  • New techniques to bring cardiac simulations closer to the clinics, for example, via the development of new models, numerical methods, and/or the use of parallel techniques
  • The use of models as a platform for the development of new treatments and drugs for cardiac pathologies, for example, to suppress cardiac arrhythmias and in particular ventricular fibrillation, to stop the progression of heart failure and hypertrophy
  • The use of models to better understand the relations between cardiac function and clinical invasive and noninvasive measurements, such as the electrocardiogram

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 626378
  • - Editorial

Simulations of Heart Function

Rodrigo Weber dos Santos | Sergio Alonso | ... | Joakim Sundnes
  • Special Issue
  • - Volume 2015
  • - Article ID 731386
  • - Research Article

A Computer Simulation Study of Anatomy Induced Drift of Spiral Waves in the Human Atrium

Sanjay R. Kharche | Irina V. Biktasheva | ... | Vadim N. Biktashev
  • Special Issue
  • - Volume 2015
  • - Article ID 530352
  • - Research Article

ECG-Based Detection of Early Myocardial Ischemia in a Computational Model: Impact of Additional Electrodes, Optimal Placement, and a New Feature for ST Deviation

Axel Loewe | Walther H. W. Schulze | ... | Gunnar Seemann
  • Special Issue
  • - Volume 2015
  • - Article ID 720575
  • - Research Article

Filament Dynamics during Simulated Ventricular Fibrillation in a High-Resolution Rabbit Heart

Pras Pathmanathan | Richard A. Gray
  • Special Issue
  • - Volume 2015
  • - Article ID 465714
  • - Review Article

Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis

Tashalee R. Brown | Trine Krogh-Madsen | David J. Christini
  • Special Issue
  • - Volume 2015
  • - Article ID 197586
  • - Research Article

Basis for the Induction of Tissue-Level Phase-2 Reentry as a Repolarization Disorder in the Brugada Syndrome

Alfonso Bueno-Orovio | Elizabeth M. Cherry | ... | Flavio H. Fenton
  • Special Issue
  • - Volume 2015
  • - Article ID 137482
  • - Research Article

Adaptive Mesh Refinement and Adaptive Time Integration for Electrical Wave Propagation on the Purkinje System

Wenjun Ying | Craig S. Henriquez
  • Special Issue
  • - Volume 2015
  • - Article ID 987293
  • - Research Article

Application of Mathematical Modeling for Simulation and Analysis of Hypoplastic Left Heart Syndrome (HLHS) in Pre- and Postsurgery Conditions

Ali Jalali | Gerard F. Jones | ... | C. Nataraj
  • Special Issue
  • - Volume 2015
  • - Article ID 621034
  • - Research Article

Image-Based Structural Modeling of the Cardiac Purkinje Network

Benjamin R. Liu | Elizabeth M. Cherry
  • Special Issue
  • - Volume 2015
  • - Article ID 713058
  • - Research Article

Simulation of Ectopic Pacemakers in the Heart: Multiple Ectopic Beats Generated by Reentry inside Fibrotic Regions

Bruno Gouvêa de Barros | Rodrigo Weber dos Santos | ... | Sergio Alonso
BioMed Research International
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Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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