BioMed Research International

Cutting-Edge Methods for Optimal Clinical Outcomes in Muscle Tissue via the Rehabilitation Rule

Publishing date
01 Mar 2022
Submission deadline
15 Oct 2021

1Universidade de Brasília, Brasília, Brazil

2University of Miami, Miami, USA

3Université de Bourgogne, Dijon, France

This issue is now closed for submissions.
More articles will be published in the near future.

Cutting-Edge Methods for Optimal Clinical Outcomes in Muscle Tissue via the Rehabilitation Rule

This issue is now closed for submissions.
More articles will be published in the near future.


Muscle tissue is the central component of human movement, acting as a bridge between neurological, skeletal, cardiovascular, and respiratory systems by enabling functional performance throughout the life of humans. Several interventions have been proposed to modulate components of muscle plasticity to improve cardiorespiratory fitness, muscle strength, balance, and flexibility to increase quality of life and life expectancy. The proposed interventions include numerous exercise methodologies and assistive technology tools, such as neuromuscular electrical stimulation (NMES), inspiratory muscle training, and many others.

From the creation of the rod-shaped myosin theory to the most recent discoveries in muscle contraction, rehabilitation interventions have been investigated and employed to improve the rehabilitation process. The interdisciplinary and transdisciplinary approach of rehabilitation teams working collaboratively, holistically, and in a patient-centered manner reduces the effects of impairments of activity limitations and participation restrictions and promotes function. Further in-depth knowledge regarding physiological muscle differences among race, age, gender, and pathophysiological conditions may lead to the development of innovative interventions and more appropriate use of existing strategies.

In this Special Issue, we invite high-quality original research and review articles examining the effects of interventions on muscle tissue linked to the modulation of neurological, musculoskeletal, cardiovascular, and respiratory systems as well as basic and applied science examining the effects of modulating muscle tissue on functional status. We aim to collect multidisciplinary and integrative research papers under the scope of clinical therapeutic interventions on muscle tissue plasticity and physiology as they relate to the International Classification of Functioning, Disability, and Health.

Potential topics include but are not limited to the following:

  • The role of rehabilitation tools to improve muscle contraction fatigability
  • The muscular response of different recovery modalities on muscle function markers, muscle damage markers, and systemic inflammation following muscle damage
  • Main cellular mechanisms involved in muscle atrophy and hypertrophy following clinical therapeutic interventions
  • Muscular wasting and systemic inflammation after critical disease
  • The role of clinical therapeutic intervention on muscle and extracellular matrix remodeling
  • Muscle strength training modalities in special populations
  • Neuromuscular electrical stimulation and muscle plasticity
  • Effects of muscular interventions on the cardiorespiratory system
  • Muscular interventions as a method to improve cardiorespiratory health
  • Peripheral vasodilation mechanisms and their influence on exercise capacity
  • Ventilatory response to exercise
  • Rehabilitation procedures to improve quality of life
  • Advances in muscle examination techniques, such as electromyography (EMG), electrical impedance myography (EIM), and mechanomyography (MMG)
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