BioMed Research International

Research Advances in Critical Care: Targeting Patients' Physiological and Psychological Outcomes


1Cyprus University of Technology, Limassol, Cyprus

2Griffith University, Brisbane, Australia

3Hadassah Hebrew University Medical Center, Jerusalem, Israel

Research Advances in Critical Care: Targeting Patients' Physiological and Psychological Outcomes


Protracted critical illness along with the ensuing complications such as sepsis and multiple organ dysfunction is an intriguing pathophysiological entity accounting for high morbidity and mortality that continue to challenge clinicians.

Recent developments show that collaborative interdisciplinary interventions targeting patients’ needs have the potential to improve survival outcomes, as well as longer-term physiological and psychological outcomes, in many critically ill individuals. These interventions include approaches such as infection control, management of sedation, agitation and pain, early progressive mobilization, palliative care, family presence, management of anxiety, and nonpharmacologic interventions to promote sleep, and they encompass the principles of bundled care and interprofessional collaboration.

With the purpose of delineating a comprehensive evidenced-based paradigm for improving critically ill patients’ outcomes, investigators are invited to submit manuscripts related to recent advances in the interdisciplinary care of critically ill individuals and of their families.

Original research articles, systematic and narrative reviews and theoretical papers are welcomed. Potential topics will address advances in comprehensive approaches that improve patients’ outcomes.

Potential topics include, but are not limited to:

  • Attenuation of systemic inflammation and prevention and management of related sequelae and infection
  • Addressing causative factors in sepsis and multiple organ dysfunction, including oxidative stress, immune and endothelial dysfunction, and neuroendocrine derangements
  • Stress response and person-centered care in critical illness
  • Recent advances in invasive and less-invasive organ system support
  • Patients positioning and mobility
  • Nutritional management
  • Patient communication and neurocognitive rehabilitation
  • Assessment and management of pain, analgesia sedation, and delirium
  • Assessment and support of sleep and circadian rhythmicity
  • Management of environmental stressors (noise, light, unit environment, etc.)
  • Supportive and palliative care
  • Family-centered care
  • Psychosocial support, spiritual support, and nonpharmacologic management of anxiety and stress (e.g., music, relaxation, imagery, etc.)
  • Interdisciplinary collaboration, and education in critical care
  • Prevention and management of longer term effects of critical illness
  • Intervention bundling


  • Special Issue
  • - Volume 2015
  • - Article ID 283067
  • - Editorial

Research Advances in Critical Care: Targeting Patients’ Physiological and Psychological Outcomes

Elizabeth Papathanassoglou | Ged Williams | Julie Benbenishty
  • Special Issue
  • - Volume 2015
  • - Article ID 635737
  • - Review Article

Defining the Role of Dexmedetomidine in the Prevention of Delirium in the Intensive Care Unit

S. Nelson | A. J. Muzyk | ... | J. P. Gagliardi
  • Special Issue
  • - Volume 2015
  • - Article ID 503830
  • - Review Article

The Impact of Pain Assessment on Critically Ill Patients’ Outcomes: A Systematic Review

Evanthia Georgiou | Maria Hadjibalassi | ... | Elizabeth D. E. Papathanassoglou
  • Special Issue
  • - Volume 2015
  • - Article ID 868653
  • - Review Article

An Integrative Literature Review of Organisational Factors Associated with Admission and Discharge Delays in Critical Care

Laura-Maria Peltonen | Louise McCallum | ... | Frances Lin
  • Special Issue
  • - Volume 2015
  • - Article ID 719497
  • - Research Article

Auditing of Monitoring and Respiratory Support Equipment in a Level III-C Neonatal Intensive Care Unit

Elena Bergon-Sendin | Carmen Perez-Grande | ... | Carmen Rosa Pallas-Alonso
  • Special Issue
  • - Volume 2015
  • - Article ID 536724
  • - Research Article

Basic Competence of Intensive Care Unit Nurses: Cross-Sectional Survey Study

Riitta-Liisa Lakanmaa | Tarja Suominen | ... | Helena Leino-Kilpi
  • Special Issue
  • - Volume 2015
  • - Article ID 424308
  • - Review Article

Is It Time to Beta Block the Septic Patient?

Philip Pemberton | Tonny Veenith | ... | Tony Whitehouse
  • Special Issue
  • - Volume 2015
  • - Article ID 876947
  • - Research Article

Symptoms of Posttraumatic Stress after Intensive Care Delirium

Helle Svenningsen | Ingrid Egerod | ... | Poul Videbech
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