BioMed Research International

Phosphorylation, Signaling, and Cancer: Targets and Targeting


Status
Published

1University of Modena, Modena, Italy

2Piqur, Basel, Switzerland

3Kyoto University, Kyoto, Japan

4George Mason University, Fairfax, USA

5University of Padova, Padova, Italy


Phosphorylation, Signaling, and Cancer: Targets and Targeting

Description

60 years after the publication, 1954, of the first report on enzymatic phosphorylation of proteins by Eugene Kennedy, protein kinases are now well-established key signaling molecules that impact all major biological processes. Several protein and lipid kinases have been recently implicated in the pathophysiology of cancer. Protein and lipid kinases are therefore a focus of both basic cancer research and drug discovery. As a result, kinase inhibitors are among the fastest growing classes of anticancer drugs. Notable advances have been made in the rational design of small-molecule inhibitors that target unique kinase conformational forms and binding sites and have specific kinase selectivity profiles. Furthermore, novel protein and oligonucleotide-based compounds that target protein kinases are being developed. Modern, high throughput techniques and better knowledge of the kinome are also very important to gear up the protein kinase drug discovery process, and they are a cornerstone for personalized cancer therapy.

In this special issue, we intend to invite front-line researchers and authors to submit original research and review articles that will shed new light on the diverse approaches to target protein kinase signaling in malignant cells.

Potential topics include, but are not limited to:

  • Validation of kinases as targets: tools and approaches
  • Targeting lipid kinases including SPHK and CERK
  • Targeting RTPKs with particular emphasis on allosteric approaches (dimerization inhibitors, etc. (mAbs))
  • Inhibition of acidophilic kinases, in vitro/in vivo
  • Inhibition of basophilic kinases, in vitro/in vivo
  • Resistance to kinase inhibition: priming, unintended feedback, reactivation of pathways, and how to solve the problem
  • Pathway-specific targeting, in vitro/in vivo
  • Protein phosphorylation as a tool to predict protein kinase sensitivity to drug targeting
  • Design and validation of kinase or multiple kinase inhibitors
  • High throughput technologies for kinase profiling
  • Inhibition of individual versus multiple pathways
  • Structure based drug discovery for kinases
  • Pseudokinases: structure-function relationships and targeting
  • A system approach to conquer the kinome space: how to tackle this and what would we learn

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 601543
  • - Editorial

Phosphorylation, Signaling, and Cancer: Targets and Targeting

Sandra Marmiroli | Doriano Fabbro | ... | Maria Ruzzene
  • Special Issue
  • - Volume 2015
  • - Article ID 185736
  • - Research Article

Different Persistence of the Cellular Effects Promoted by Protein Kinase CK2 Inhibitors CX-4945 and TDB

Cristina Girardi | Daniele Ottaviani | ... | Maria Ruzzene
  • Special Issue
  • - Volume 2015
  • - Article ID 734127
  • - Research Article

The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation

Giorgio Cozza | Andrea Venerando | ... | Lorenzo A. Pinna
  • Special Issue
  • - Volume 2015
  • - Article ID 914645
  • - Research Article

Trigonella foenum (Fenugreek) Induced Apoptosis in Hepatocellular Carcinoma Cell Line, HepG2, Mediated by Upregulation of p53 and Proliferating Cell Nuclear Antigen

Mahmoud I. M. Khalil | Mohamed M. Ibrahim | ... | Ahmed S. Sultan
  • Special Issue
  • - Volume 2015
  • - Article ID 404368
  • - Research Article

All-Trans Retinoic Acid Induces Proliferation, Survival, and Migration in A549 Lung Cancer Cells by Activating the ERK Signaling Pathway through a Transcription-Independent Mechanism

Reyna Sara Quintero Barceinas | Alejandro García-Regalado | ... | Claudia Haydée González-De la Rosa
  • Special Issue
  • - Volume 2015
  • - Article ID 761501
  • - Research Article

Helicobacter pylori CagA Suppresses Apoptosis through Activation of AKT in a Nontransformed Epithelial Cell Model of Glandular Acini Formation

Gabriela Vallejo-Flores | Javier Torres | ... | Ezequiel M. Fuentes-Pananá
  • Special Issue
  • - Volume 2015
  • - Article ID 973912
  • - Research Article

Inhibition of PI3K Signalling Selectively Affects Medulloblastoma Cancer Stem Cells

Chiara Frasson | Elena Rampazzo | ... | Luca Persano
  • Special Issue
  • - Volume 2015
  • - Article ID 870918
  • - Research Article

Activity of BKM120 and BEZ235 against Lymphoma Cells

Monica Civallero | Maria Cosenza | ... | Stefano Sacchi
  • Special Issue
  • - Volume 2014
  • - Article ID 747415
  • - Research Article

KML001, a Telomere-Targeting Drug, Sensitizes Glioblastoma Cells to Temozolomide Chemotherapy and Radiotherapy through DNA Damage and Apoptosis

Seon Rang Woo | Yunhee Ham | ... | Do-Hyun Nam
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
 Submit