Many countries have continuously seen an increasing number of people living with HIV/AIDS (PLWH), largely due to the expanded HIV testing efforts that lead to the identification of more new infections and highly active antiretroviral therapy (ART) introduction that prolongs the life of PLWH. In 2014, the UNAIDS and partners launched the 90–90–90 targets on knowing HIV status, receiving treatment, and achieving viral suppression to end the HIV/AIDS epidemic by 2020, and a fourth 90 target on quality of life was also proposed recently.

Now it is the time to examine the gaps in meeting these targets and summarize the evidence-based interventions for reducing the gaps, particularly for HIV care, which spans the last three 90 targets. Rigorous studies on evaluating progress towards the 90-90-90 targets, interventions to close the gaps in the HIV continuity of care and maintain viral suppression, “positive prevention” strategies, mathematical modeling that evaluate the impact of combination interventions, co-morbidities and sexually transmitted infections, are needed.

The aim of this Special Issue is to collate evidence-based manuscripts on relevant topics in this field. Research articles, clinical studies, meta-analysis, and reviews are all welcome.

Potential topics include but are not limited to the following:

• Observational or interventional research on engaging newly diagnosed HIV-infected individuals (either clinic-based or self-testing) to HIV care, and re-engaging those who lost to HIV care, particularly among key populations such as MSM and elderly people
• Gaps in the HIV continuum of care
• Treatment for co-morbid diseases such as metabolic syndrome, diabetes, hepatitis, TB, cardiovascular disease, kidney disease, and bone diseases
• Weight gain in HIV-infected subjects and implications for treatment
• Anxiety, depression, sleeping disorder, and other mental health issues facing HIV patients
• Life quality of HIV patients and stigma and confidentiality facing HIV care
• Neuro-cognitive disorders among HIV patients
• Mathematical modelling of HIV care
• Control of sexually transmitted infections
• Pre-exposure prophylaxis and post-exposure prophylaxis against HIV
• Clinical trials in HIV care
• HIV and aging