BioMed Research International

Animal Models of Human Pathology 2016


Status
Published

Lead Editor

1Institute of Experimental Endocrinology and Oncology, Naples, Italy

2Santiago University, Santiago de Compostela, Spain

3The Ohio State University, Columbus, USA


Animal Models of Human Pathology 2016

Description

Based on the genetic alterations found in humans, multiple models of human pathologies have been generated in genetically engineered or drug-induced animals. These experimental models are valuable tools for understanding physiopathology of the disease and discovering novel therapeutic targets and drugs. In fact, one avenue holding tremendous potential to find therapies against human diseases is the use of intact living systems, where complex biological processes can be examined.

We invite authors to present original research articles as well as review articles that will stimulate the continuing efforts in developing animal models, ranging from invertebrates to large animals, to be used in preclinical applications, improving therapy in various fields of medicine (oncology, cardiovascular field, immunology, endocrinology, brain pathologies, etc.). We are particularly interested in manuscripts that report naturally occurring, induced, or engineered animal models of human diseases and their preclinical applications. Reviews that summarize all the animal models for a particular pathology, their involvement in preclinical trials, and their future in treatment practice are also particularly welcome.

Potential topics include, but are not limited to:

  • Modeling glioblastoma in rodents
  • The use of animal models in the study of obesity
  • The value of animal models for drug development in autoimmune diseases
  • The genetics of cardiovascular disease: new insights from animal models
  • Understanding pathogenesis and therapy of ataxia telangiectasia (AT) via animal models
  • Experimental animal models of rheumatoid arthritis, lupus erythematosus, and osteoarthritis
  • Small model organisms for neurodegenerative diseases
  • Large animal models of heart failure
  • The pig: a representative animal model for humans
  • Modeling human disease using the nematode Caenorhabditis elegans
  • Drosophila models of human diseases
  • Zebrafish models in oncology

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 4023982
  • - Editorial

Animal Models of Human Pathology 2016

Monica Fedele | Oreste Gualillo | Andrea Vecchione
  • Special Issue
  • - Volume 2016
  • - Article ID 1715053
  • - Research Article

Tumor Take Rate Optimization for Colorectal Carcinoma Patient-Derived Xenograft Models

Michael Gock | Florian Kühn | ... | Michael Linnebacher
  • Special Issue
  • - Volume 2016
  • - Article ID 1627184
  • - Research Article

A Novel Murine Model of Parvovirus Associated Dilated Cardiomyopathy Induced by Immunization with VP1-Unique Region of Parvovirus B19

Julijus Bogomolovas | Egidijus Šimoliūnas | ... | Siegfried Labeit
  • Special Issue
  • - Volume 2016
  • - Article ID 3819052
  • - Research Article

Transneuronal Degeneration of Thalamic Nuclei following Middle Cerebral Artery Occlusion in Rats

Shu-Jen Chang | Juin-Hong Cherng | ... | Ming-Lun Hsu
  • Special Issue
  • - Volume 2016
  • - Article ID 2518626
  • - Research Article

Beneficial Effect of Short Pretransplant Period of Hypothermic Pulsatile Perfusion of the Warm-Ischemic Kidney after Cold Storage: Experimental Study

Alberto Lázaro | Blanca Humanes | ... | Enrique Lledó-García
  • Special Issue
  • - Volume 2016
  • - Article ID 9085273
  • - Research Article

Systematic Analysis of the Cytokine and Anhedonia Response to Peripheral Lipopolysaccharide Administration in Rats

Steven Biesmans | Liam J. R. Matthews | ... | Luc Ver Donck
  • Special Issue
  • - Volume 2016
  • - Article ID 7261960
  • - Research Article

Effects of Erythropoietin Administration on Adrenal Glands of Landrace/Large White Pigs after Ventricular Fibrillation

Armando Faa | Gavino Faa | ... | Theodoros Xanthos
  • Special Issue
  • - Volume 2016
  • - Article ID 5251738
  • - Research Article

Progressive Depletion of Rough Endoplasmic Reticulum in Epithelial Cells of the Small Intestine in Monosodium Glutamate Mice Model of Obesity

Kazuhiko Nakadate | Kento Motojima | ... | Sawako Tanaka-Nakadate
  • Special Issue
  • - Volume 2016
  • - Article ID 1414383
  • - Review Article

Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer

Michael A. Mcilhatton | Gregory P. Boivin | Joanna Groden
  • Special Issue
  • - Volume 2016
  • - Article ID 9704607
  • - Research Article

Animal Model of Gestational Diabetes Mellitus with Pathophysiological Resemblance to the Human Condition Induced by Multiple Factors (Nutritional, Pharmacological, and Stress) in Rats

Siti Hajar Abdul Aziz | Cini Mathew John | ... | Fazlin Mohd Fauzi
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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