BioMed Research International

Extraskeletal Functions of Vitamin D


Status
Published

1AOU G. Martino University of Messina, Messina, Italy

2Comenius University, Bratislava, Slovakia

3University Hospital (CHUV), Lausanne, Switzerland

4Second University of Naples, Naples, Italy


Extraskeletal Functions of Vitamin D

Description

The recent identification of an expanded role of vitamin D action, beyond bone and mineral disorders, and the new investigational approaches, opened the interest of many researchers in this field. In addition to the classic vitamin D actions, a new spectrum of vitamin D activities that include important effects on cellular proliferation, differentiation, and the immune system has been identified. All these effects have led to a consideration of the potential application of vitamin D therapy to a wide range of diseases. Moreover, this therapeutic potential has conducted the pharmaceutical research to the discovery of new vitamin D analogs that might have a more favourable therapeutic profile, with less unfavourable effects such as hypercalcemia and hypercalciuria.

These new therapeutic applications range from renal disease (proteinuria and inflammation fibrosis) to psoriasis, from immunomodulation to cancer, from infectious disease to obesity and malnutrition, and from diabetes mellitus to cardiovascular disease. Moreover, studies on vitamin D receptor polymorphism showed that an altered signalling of vitamin D may lead to a particular predisposition to several diseases.

Potential topics include, but are not limited to:

  • Interactions between vitamin D and renal disease
  • Role of activation of vitamin D receptor (VDR) in cardiovascular disease
  • Vitamin D and infectious disease: role in innate immunity
  • Obesity and malnutrition: role of vitamin D status
  • Immunomodulatory effects of vitamin D
  • Role of polymorphisms of vitamin D
  • Vitamin D in neoplastic disease
  • Vitamin D, insulin sensitivity, and glucose metabolism
  • Vitamin D and skin disease

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 294719
  • - Editorial

Extraskeletal Functions of Vitamin D

Domenico Santoro | Katarina Sebekova | ... | Luca De Nicola
  • Special Issue
  • - Volume 2015
  • - Article ID 783538
  • - Research Article

Paricalcitol Inhibits Aldosterone-Induced Proinflammatory Factors by Modulating Epidermal Growth Factor Receptor Pathway in Cultured Tubular Epithelial Cells

Jose L. Morgado-Pascual | Sandra Rayego-Mateos | ... | Marta Ruiz-Ortega
  • Special Issue
  • - Volume 2015
  • - Article ID 563403
  • - Review Article

Role of Vitamin D Deficiency in Extraskeletal Complications: Predictor of Health Outcome or Marker of Health Status?

Idris Guessous
  • Special Issue
  • - Volume 2015
  • - Article ID 492365
  • - Research Article

Vitamin D Binding Protein Is Not Involved in Vitamin D Deficiency in Patients with Chronic Kidney Disease

Marta Kalousova | Sylvie Dusilova-Sulkova | ... | Tomas Zima
  • Special Issue
  • - Volume 2015
  • - Article ID 807673
  • - Clinical Study

The Impact of Vitamin D3 Supplementation on Mechanisms of Cell Calcium Signaling in Chronic Kidney Disease

Ingrid Lajdova | Viera Spustova | ... | Alzbeta Marcek Chorvatova
  • Special Issue
  • - Volume 2015
  • - Article ID 145828
  • - Review Article

Interplay of Vitamin D, Erythropoiesis, and the Renin-Angiotensin System

Domenico Santoro | Daniela Caccamo | ... | Luca De Nicola
  • Special Issue
  • - Volume 2015
  • - Article ID 958097
  • - Research Article

Is Vitamin D Deficiency Related to Accumulation of Advanced Glycation End Products, Markers of Inflammation, and Oxidative Stress in Diabetic Subjects?

K. Šebeková | M. Stürmer | ... | A. Heidland
  • Special Issue
  • - Volume 2015
  • - Article ID 735615
  • - Review Article

Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder

Pasquale Mansueto | Aurelio Seidita | ... | Antonio Cascio
  • Special Issue
  • - Volume 2015
  • - Article ID 986281
  • - Review Article

The Pleiotropic Effects of Vitamin D in Gynaecological and Obstetric Diseases: An Overview on a Hot Topic

Francesca Colonese | Antonio Simone Laganà | ... | Onofrio Triolo
  • Special Issue
  • - Volume 2015
  • - Article ID 470805
  • - Review Article

Vitamin D and Inflammatory Bowel Disease

Marco Ardesia | Guido Ferlazzo | Walter Fries
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
 Submit

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.