BioMed Research International

Recent Advances in the Biology of the Urothelium and Applications for Urinary Bladder Dysfunction


Publishing date
18 Jul 2014
Status
Published
Submission deadline
28 Feb 2014

Lead Editor

1Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

2Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden

3Department of Urology, Dankook University College of Medicine, Cheonan, Republic of Korea


Recent Advances in the Biology of the Urothelium and Applications for Urinary Bladder Dysfunction

Description

The urinary bladder is an organ for short-term storage of urine. Therefore it has to be adapted to constant distension-contraction cycles and it has to constantly prevent waste substances of urine to reenter the circulatory system. In mammals, the urinary bladder wall is comprised of adventitia, detrusor muscle, submucosa, and mucosa, which in turn consists of the lamina propria and the urothelium. It is the urothelium that acts as the permeability barrier. This tight barrier mainly depends on the unique structure of the apical plasma membrane of superficial cells, called umbrella cells, to tight junctions between them. The traditional way of looking at the urothelium as a simple barrier is now challenged by numerous findings showing that the urothelium may also sense changes in the extracellular environment and transduce signals to nerves and muscles in the bladder wall. Highly differentiated normal urothelium is a very stable tissue, but it has a great capacity for quick regeneration when challenged by mechanical or chemical stimuli.

Different diseases affecting the urinary bladder and causing bladder dysfunction may compromise the permeability barrier as well as disrupt the urothelial-associated sensory web. Knowledge and understanding of these processes will lead to improved therapeutic strategies. One of the potential strategies for treatment of several urologic diseases is tissue engineering, which aims to provide a temporary scaffold for repair of affected bladder tissue.

We invite investigators to contribute original research articles as well as review articles on structure, function, differentiation of the normal and pathological urinary bladder, and tissue engineering-based approaches for the treatment of bladder diseases. Focus is on and around the urothelium. Potential topics include, but are not limited to:

  • Urothelial cell differentiation
  • Membrane structure and traffic in urothelial cells
  • Permeability of the bladder wall
  • Molecular and morpho-functional aspect of bladder diseases
  • Receptors, channels, and signalling molecules in the urinary bladder
  • Urothelial impact on afferent signalling, efferent signalling, and detrusor activity
  • Development of scaffolds for bladder repair
  • Latest methodologies for analysing structure and function of bladder cells and tissues

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/urology/uroth/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 341787
  • - Editorial

Recent Advances in the Biology of the Urothelium and Applications for Urinary Bladder Dysfunction

Rok Romih | Michael Winder | Gilho Lee
  • Special Issue
  • - Volume 2014
  • - Article ID 359179
  • - Research Article

Inhibition of Nitric Oxide Synthase Prevents Muscarinic and Purinergic Functional Changes and Development of Cyclophosphamide-Induced Cystitis in the Rat

Patrik Aronsson | Renata Vesela | ... | Gunnar Tobin
  • Special Issue
  • - Volume 2014
  • - Article ID 204604
  • - Research Article

ATP during Early Bladder Stretch Is Important for Urgency in Detrusor Overactivity Patients

Y. Cheng | K. J. Mansfield | ... | K. H. Moore
  • Special Issue
  • - Volume 2014
  • - Article ID 347616
  • - Research Article

Luminal DMSO: Effects on Detrusor and Urothelial/Lamina Propria Function

Katrina J. Smith | Russ Chess-Williams | Catherine McDermott
  • Special Issue
  • - Volume 2014
  • - Article ID 987149
  • - Review Article

Bladder Cancer and Urothelial Impairment: The Role of TRPV1 as Potential Drug Target

Francesco Mistretta | Nicolò Maria Buffi | ... | Massimo Lazzeri
  • Special Issue
  • - Volume 2014
  • - Article ID 865463
  • - Review Article

Evidence for Bladder Urothelial Pathophysiology in Functional Bladder Disorders

Susan K. Keay | Lori A. Birder | Toby C. Chai
  • Special Issue
  • - Volume 2014
  • - Article ID 473536
  • - Review Article

Cystitis: From Urothelial Cell Biology to Clinical Applications

Gilho Lee | Rok Romih | Daša Zupančič
  • Special Issue
  • - Volume 2014
  • - Article ID 805236
  • - Research Article

Correlation between Urothelial Differentiation and Sensory Proteins P2X3, P2X5, TRPV1, and TRPV4 in Normal Urothelium and Papillary Carcinoma of Human Bladder

Igor Sterle | Daša Zupančič | Rok Romih
  • Special Issue
  • - Volume 2014
  • - Article ID 182862
  • - Research Article

Effect of Inflammatory Mediators on ATP Release of Human Urothelial RT4 Cells

Kylie J. Mansfield | Jessica R. Hughes
  • Special Issue
  • - Volume 2014
  • - Article ID 754596
  • - Research Article

Alterations of the Myovesical Plexus of the Human Overactive Detrusor

Kamiel A. J. Kuijpers | John P. F. A. Heesakkers | Jack A. Schalken
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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