BioMed Research International

Endothelium in Diseased States


Publishing date
04 Apr 2014
Status
Published
Submission deadline
15 Nov 2013

Lead Editor

1Laboratory of Neurohumoral Regulation of Haemodynamics, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Sienkiewiczova 1, 813 71 Bratislava, Slovak Republic

2LUNAM Université, INSERM UMR U1063, Université d’Angers IBS-IRIS, Rue des Capucins, Angers, France

3Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Arzobispo Morcillo 4, 280 29 Madrid, Spain

4Department of Biomedicine, Aarhus University, Ole Worms Alle 4, Bygning 1163, 8000 Aarhus, Denmark


Endothelium in Diseased States

Description

Endothelium is the largest endocrine organ which is essential for maintenance of homeostasis of the entire body. Endothelium operates by a broad spectrum of signaling molecules controlling the contractile state of vascular smooth muscles; long distance intercellular synchronization within the vascular wall; adhesive, coagulant, and rheological properties of blood; permeability of vascular wall and dialyses of surrounding tissues. Dysfunctions in these signaling pathways not only result in the loss of important homeostatic functions but also engage endothelium into the propathological activities. This pattern shows the two sides of the coin; thus endothelium might be either good or bad guy depending on the default signaling. Endothelial dysfunction was observed in aging as well as in major lifestyle-related diseases. This suggests that the endothelium can serve as a target for prevention and treatment of diseased states. Currently there is an intensive development in identification of new endothelium-dependent signaling pathways and characterization of their role for various pathological states and disease development. This issue aims at helping this progress.

We invite investigators to contribute original research articles as well as review articles that document the role of endothelium in maintenance of physiological functions as well as in development of diseased states. We are also interested in studies investigating the risk factors in endothelial dysfunction development or aimed at its prevention and treatment. Potential topics include, but are not limited to:

  • New mechanistic insights into action of endothelium-derived relaxing and contracting factors, oxidative and nitrosative stress
  • New methods in determination of endothelial dysfunction and vascular cell-to-cell communication
  • Risk factors in development of endothelial dysfunction: fetal programming, stress, and obesity
  • Endothelial alterations in diseased states: hypertension, atherosclerosis, coronary heart disease, diabetes, renal disorders, brain disorders, and hypoxic conditions
  • New approaches in prevention and therapy of endothelial dysfunction: diet, exercise, and new drugs

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/cardiology/edss/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 591918
  • - Clinical Study

Brachial Artery Endothelial Responses during Early Recovery from an Exercise Bout in Patients with Coronary Artery Disease

Katharine D. Currie | Robert S. McKelvie | Maureen J. MacDonald
  • Special Issue
  • - Volume 2014
  • - Article ID 801896
  • - Review Article

Endothelium and Its Alterations in Cardiovascular Diseases: Life Style Intervention

Gaia Favero | Corrado Paganelli | ... | Rita Rezzani
  • Special Issue
  • - Volume 2014
  • - Article ID 610474
  • - Research Article

Nitric Oxide and Superoxide Anion Balance in Rats Exposed to Chronic and Long Term Intermittent Hypoxia

Patricia Siques | Ángel Luis López de Pablo | ... | M. Rosario López
  • Special Issue
  • - Volume 2014
  • - Article ID 501612
  • - Review Article

The Endothelial ADMA/NO Pathway in Hypoxia-Related Chronic Respiratory Diseases

Nicole Lüneburg | Lars Harbaum | Jan K. Hennigs
  • Special Issue
  • - Volume 2014
  • - Article ID 128046
  • - Research Article

Endothelial Function in a Mouse Model of Myeloperoxidase Deficiency

Veronika Golubinskaya | Ulla Brandt-Eliasson | ... | Holger Nilsson
  • Special Issue
  • - Volume 2014
  • - Article ID 289361
  • - Research Article

Contribution of Ca2+-Dependent Cl Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing

Silvia Liskova | Miriam Petrova | ... | Josef Zicha
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore4.100
Journal Citation Indicator0.610
Impact Factor3.411
 Submit

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.