BioMed Research International

Endothelium in Diseased States

Publishing date
04 Apr 2014
Submission deadline
15 Nov 2013

Lead Editor

1Laboratory of Neurohumoral Regulation of Haemodynamics, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Sienkiewiczova 1, 813 71 Bratislava, Slovak Republic

2LUNAM Université, INSERM UMR U1063, Université d’Angers IBS-IRIS, Rue des Capucins, Angers, France

3Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Arzobispo Morcillo 4, 280 29 Madrid, Spain

4Department of Biomedicine, Aarhus University, Ole Worms Alle 4, Bygning 1163, 8000 Aarhus, Denmark

Endothelium in Diseased States


Endothelium is the largest endocrine organ which is essential for maintenance of homeostasis of the entire body. Endothelium operates by a broad spectrum of signaling molecules controlling the contractile state of vascular smooth muscles; long distance intercellular synchronization within the vascular wall; adhesive, coagulant, and rheological properties of blood; permeability of vascular wall and dialyses of surrounding tissues. Dysfunctions in these signaling pathways not only result in the loss of important homeostatic functions but also engage endothelium into the propathological activities. This pattern shows the two sides of the coin; thus endothelium might be either good or bad guy depending on the default signaling. Endothelial dysfunction was observed in aging as well as in major lifestyle-related diseases. This suggests that the endothelium can serve as a target for prevention and treatment of diseased states. Currently there is an intensive development in identification of new endothelium-dependent signaling pathways and characterization of their role for various pathological states and disease development. This issue aims at helping this progress.

We invite investigators to contribute original research articles as well as review articles that document the role of endothelium in maintenance of physiological functions as well as in development of diseased states. We are also interested in studies investigating the risk factors in endothelial dysfunction development or aimed at its prevention and treatment. Potential topics include, but are not limited to:

  • New mechanistic insights into action of endothelium-derived relaxing and contracting factors, oxidative and nitrosative stress
  • New methods in determination of endothelial dysfunction and vascular cell-to-cell communication
  • Risk factors in development of endothelial dysfunction: fetal programming, stress, and obesity
  • Endothelial alterations in diseased states: hypertension, atherosclerosis, coronary heart disease, diabetes, renal disorders, brain disorders, and hypoxic conditions
  • New approaches in prevention and therapy of endothelial dysfunction: diet, exercise, and new drugs

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:


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Nicole Lüneburg | Lars Harbaum | Jan K. Hennigs
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Veronika Golubinskaya | Ulla Brandt-Eliasson | ... | Holger Nilsson
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Silvia Liskova | Miriam Petrova | ... | Josef Zicha
BioMed Research International
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