BioMed Research International

Gene-Gene Interaction in Maternal and Perinatal Research


Publishing date
01 Feb 2010
Status
Published
Submission deadline
01 Aug 2009

Lead Editor

1The Computational Genomics Lab, Department of Epidemiology, Michigan State University, East Lansing, MI 48824, USA

2Division of Genetic Epidemiology, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA

3Departments of Biostatistics and Human Genetics, The University of California, Los Angeles, CA 90095, USA


Gene-Gene Interaction in Maternal and Perinatal Research

Description

The interplay between a mother's genes and those of her fetus has been studied as causes of a number of pregnancy complications, such as gestational hypertension and gestational diabetes. Maternal-fetal genotype (MFG) incompatibility, in particular, has been reported to play a crucial role in the development of a number of disorders during and after the pregnancy, including preeclampsia, small for gestational age neonates, childhood autism, and schizophrenia. Although this genetic conflict has long been suspected to be responsible for these and other disorders, rigorous modeling and quantitative analysis of the maternal gene-offspring gene interaction and more generally any gene-gene interaction have only been recently feasible—thanks to the development of biotechnology. It is hoped that a thorough understanding of gene-gene interactions will lead to major breakthroughs in prevention, treatment, and therapeutics specific to maternal and perinatal diseases.

The main focus of this special issue will be on gene-gene interaction in maternal and perinatal research, leading to either beneficial or detrimental outcomes of pregnancy, through genetic linkage and association studies, either by a candidate gene or a genome-wide approach, with the theme of modeling gene-gene interactions. It is anticipated that this Special Issue will become an international forum for researchers to communicate and present their most recent findings, to review and summarize past discoveries, and to foresee prospects for future studies in this area. The topics to be covered, as related to maternal and perinatal health and disease, include but are not limited to:

  • Modeling gene-gene interactions
  • Study design and data analysis for genetic detection of maternal or perinatal risk factors
  • Specific genetic studies and findings relating to maternal or perinatal diseases
  • Reviews
  • Meta-analysis methods for gene-gene interactions
  • Modeling missing data in genetic studies to detect interactions
  • MFG incompatibility and testing
  • Controlling for multiple comparisons
  • Maternal genetic effects as risk factors for offspring disease

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jbb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 853612
  • - Editorial

Gene-Gene Interaction in Maternal and Perinatal Research

Janet S. Sinsheimer | Robert C. Elston | Wenjiang J. Fu
  • Special Issue
  • - Volume 2010
  • - Article ID 369534
  • - Research Article

Detection of Fetomaternal Genotype Associations in Early-Onset Disorders: Evaluation of Different Methods and Their Application to Childhood Leukemia

Jasmine Healy | Mathieu Bourgey | ... | Marie-Helene Roy-Gagnon
  • Special Issue
  • - Volume 2010
  • - Article ID 543514
  • - Research Article

The Relationship between Birthweight and Longitudinal Changes of Blood Pressure Is Modulated by Beta-Adrenergic Receptor Genes: The Bogalusa Heart Study

Wei Chen | Sathanur R. Srinivasan | ... | Gerald S. Berenson
  • Special Issue
  • - Volume 2010
  • - Article ID 478732
  • - Review Article

Maternal-Zygotic Epistasis and the Evolution of Genetic Diseases

Nicholas K. Priest | Michael J. Wade
  • Special Issue
  • - Volume 2010
  • - Article ID 576318
  • - Review Article

Evidence for Maternal-Fetal Genotype Incompatibility as a Risk Factor for Schizophrenia

Christina G. S. Palmer
  • Special Issue
  • - Volume 2010
  • - Article ID 321082
  • - Review Article

Genetic Risk for Recurrent Urinary Tract Infections in Humans: A Systematic Review

M. Zaffanello | G. Malerba | ... | V. Fanos
  • Special Issue
  • - Volume 2010
  • - Article ID 396184
  • - Research Article

Association of Combined Maternal-Fetal TNF- Gene G308A Genotypes with Preterm Delivery: A Gene-Gene Interaction Study

Mingbin Liang | Xun Wang | ... | Dafang Chen
  • Special Issue
  • - Volume 2010
  • - Article ID 787545
  • - Research Article

Gene Expression Profiling of Placentas Affected by Pre-Eclampsia

Anne Mette Hoegh | Rehannah Borup | ... | Thomas V. F. Hviid
  • Special Issue
  • - Volume 2010
  • - Article ID 630940
  • - Research Article

Gene-Gene Interactions in the Folate Metabolic Pathway and the Risk of Conotruncal Heart Defects

Philip J. Lupo | Elizabeth Goldmuntz | Laura E. Mitchell
BioMed Research International
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