BioMed Research International

Cytokines in Systemic Lupus Erythematosus


Publishing date
15 Sep 2010
Status
Published
Submission deadline
15 Jan 2010

1Brigham Young University, Provo, UT 84601, USA

2Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA

3Pathology Department, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA


Cytokines in Systemic Lupus Erythematosus

Description

Systemic lupus erythematosus (SLE) is a disease of a dysregulated immune system. As some of the principal modifiers of immune responses, cytokines figure prominently into the etiology and pathogenesis of SLE. Cytokines can be products of both the innate and the adaptive immune systems and affect the majority of the cell types involved in lupus. Recent work using microarray techniques and genetic analysis has strengthened the association between cytokine dysregulation and SLE. Furthermore, cytokines represent a relatively easy target for therapeutic intervention via blockade with biological agents, such as the recently announced encouraging trials of inhibitors to Blys. A thorough understanding of the role these important immune control molecules play in SLE is crucial to understanding the disease and how to ameliorate its effects.

We invite authors to present original research articles as well as review articles that will stimulate work in the evolving area of cytokine biology in SLE. We are particularly interested in papers that address the role of cytokines in the etiology of SLE, or targeting of cytokines as part of an SLE therapeutic strategy. Topics that will be emphasized include, but are not limited to:

  • Genetic associations with cytokine profile in SLE
  • Identification of cytokine dysregulation in SLE
  • Use of cytokines as SLE biomarkers
  • Animal studies that identify the importance of cytokines or groups of cytokines in an SLE model
  • The role of IL-6, IL-10, IL-17, BLyS, interferons, or TNF-family members in SLE
  • Influence of SLE-associated cytokines upon cellular immunity and/or humoral autoimmunity
  • Clinical associations with cytokine patterns in SLE
  • Therapeutic strategies for SLE involving cytokines

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jbb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 735169
  • - Editorial

Cytokines in Systemic Lupus Erythematosus

Brian D. Poole | Timothy B. Niewold | ... | Charles S. Via
  • Special Issue
  • - Volume 2010
  • - Article ID 607084
  • - Review Article

Accelerated Atherosclerosis in Systemic Lupus Erythematosus: Role of Proinflammatory Cytokines and Therapeutic Approaches

Chary López-Pedrera | Maria Ángeles Aguirre | ... | Maria José Cuadrado
  • Special Issue
  • - Volume 2010
  • - Article ID 509021
  • - Research Article

Reduced Expression of TCR Zeta Is Involved in the Abnormal Production of Cytokines by Peripheral T Cells of Patients with Systemic Lupus Erythematosus

Keiko Yoshimoto | Yumiko Setoyama | ... | Tsutomu Takeuchi
  • Special Issue
  • - Volume 2010
  • - Article ID 461641
  • - Review Article

Therapeutic Strategies for SLE Involving Cytokines: Mechanism-Oriented Therapies Especially IFN- 𝛾 Targeting Gene Therapy

Toshiharu Hayashi
  • Special Issue
  • - Volume 2010
  • - Article ID 706825
  • - Research Article

The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus

Isaac T. W. Harley | Timothy B. Niewold | ... | Judith A. James
  • Special Issue
  • - Volume 2010
  • - Article ID 826434
  • - Research Article

Promoter Variant of PIK3C3 Is Associated with Autoimmunity against Ro and Sm Epitopes in African-American Lupus Patients

Silvia N. Kariuki | Beverly S. Franek | ... | Timothy B. Niewold
  • Special Issue
  • - Volume 2010
  • - Article ID 569053
  • - Research Article

Increased Expression of Ganglioside GM1 in Peripheral CD4+ T Cells Correlates Soluble Form of CD30 in Systemic Lupus Erythematosus Patients

Lingli Dong | Shaoxian Hu | ... | Hisanori Umehara
  • Special Issue
  • - Volume 2010
  • - Article ID 268436
  • - Review Article

Cytokines and Chemokines in Neuropsychiatric Syndromes of Systemic Lupus Erythematosus

Hiroshi Okamoto | Akiko Kobayashi | Hisashi Yamanaka
  • Special Issue
  • - Volume 2010
  • - Article ID 457146
  • - Review Article

Cytokine Overproduction, T-Cell Activation, and Defective T-Regulatory Functions Promote Nephritis in Systemic Lupus Erythematosus

Marco Tucci | Stefania Stucci | ... | Francesco Silvestris
  • Special Issue
  • - Volume 2010
  • - Article ID 948364
  • - Review Article

Interferon Alpha in Systemic Lupus Erythematosus

Timothy B. Niewold | Daniel N. Clark | ... | Brian D. Poole
BioMed Research International
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