BioMed Research International

Molecular and Cellular Mechanisms of Neuroinflammation


Status
Published

Lead Editor

1Magna Graecia University, Calabria, Italy

2University of Camerino, Marche, Italy


Molecular and Cellular Mechanisms of Neuroinflammation

Description

In the central nervous system (CNS), the innate immune response plays a significant role in both physiological and pathological conditions. CNS diseases including traumatic brain injury, ischemic stroke, brain tumor, and cerebrovascular and neurodegenerative diseases trigger a cascade of events broadly defined as neuroinflammation, which is characterized by the activation of the microglia and astrocyte population. Reactive microglia and astrocytes potentially cause injury to the blood-brain barrier and account for neuronal impairment.

Microglia/macrophages are major cells in an organism’s immune system, and they play important roles in CNS repair and regeneration. While microglia are derived from primitive macrophages during brain development, monocyte-derived macrophages are recruited from the blood following injury or disease. Functionally differentiated microglia and macrophages are commonly subdivided into two categories: the classically activated phenotype (M1), which is characterized by the secretion of proinflammatory and cytotoxic mediators, and the alternatively activated phenotype (M2), involved in tissue repair and remodeling. Similarly, the potential roles of reactive astrocytes, NG2-positive cells, oligodendrocytes, and endothelial cells and neurons in the neuroinflammatory process have been recently established.

The aim of this special issue is to publish high-quality research papers as well as review articles addressing recent advances on the cellular and molecular mechanisms of neuroinflammation. We encourage submission of manuscript exploring the cross-talk microglia/macrophage-astrocyte/neuron and its role in different CNS diseases.

Potential topics include but are not limited to the following:

  • All potential causes of neuroinflammation (infection, neurodegenerative disorders, vascular dementia, teratogenesis, brain tumors, obesity, hypertension, autoimmunity, and toxic exposure)
  • Mechanisms driving physiological outcomes of neuroinflammation (i.e., tissue-repair response and adaption to stress)
  • Mechanisms driving pathological outcomes of inflammation (i.e., tissue damage and tumor growth)

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 8417183
  • - Editorial

Molecular and Cellular Mechanisms of Neuroinflammation

Anna Di Vito | Giuseppe Donato | Daniele Tomassoni
  • Special Issue
  • - Volume 2017
  • - Article ID 5071786
  • - Review Article

Modulating Neuroinflammation to Treat Neuropsychiatric Disorders

Franziska A. Radtke | Gareth Chapman | ... | Yasir A. Syed
  • Special Issue
  • - Volume 2017
  • - Article ID 6423021
  • - Review Article

Bioinformatics Genes and Pathway Analysis for Chronic Neuropathic Pain after Spinal Cord Injury

Guan Zhang | Ping Yang
  • Special Issue
  • - Volume 2017
  • - Article ID 3706018
  • - Research Article

Markers of Alzheimer’s Disease in Primary Visual Cortex in Normal Aging in Mice

Luis Fernando Hernández-Zimbrón | Montserrat Perez-Hernández | ... | Edgar Zenteno
  • Special Issue
  • - Volume 2017
  • - Article ID 7949582
  • - Review Article

Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity

Roger Maldonado-Ruiz | Lizeth Fuentes-Mera | Alberto Camacho
  • Special Issue
  • - Volume 2017
  • - Article ID 6823209
  • - Research Article

Peripheral Inhibitor of AChE, Neostigmine, Prevents the Inflammatory Dependent Suppression of GnRH/LH Secretion during the Follicular Phase of the Estrous Cycle

Andrzej P. Herman | Janina Skipor | ... | Dorota Tomaszewska-Zaremba
  • Special Issue
  • - Volume 2017
  • - Article ID 1549194
  • - Review Article

Proximate Mediators of Microvascular Dysfunction at the Blood-Brain Barrier: Neuroinflammatory Pathways to Neurodegeneration

Barry W. Festoff | Ravi K. Sajja | Luca Cucullo
BioMed Research International
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Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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