BioMed Research International

Functional Genomics, Genetics, and Bioinformatics


Publishing date
21 Nov 2014
Status
Published
Submission deadline
04 Jul 2014

1Department of Internal Medicine, Rush University Cancer Center, Rush University Medical Center, Chicago, IL, USA

2Department of Medicine, University of Chicago, Chicago, IL, USA

3Department of Bioengineering, Binghamton University, Binghamton, NY, USA

4Ningbo University, School of Medicine, Ningbo, Zhejiang, China


Functional Genomics, Genetics, and Bioinformatics

Description

Biology has become the land of the “-omics,” including genomics, transcriptomics, proteomics, lipidomics, and metabolomics. Each of these “-omics” generates a huge amount of high-throughput data, and it is a challenge both to analyze these data and to further investigate the function of specific molecules. Though more genomes have been completed due to the rapid development of sequencing technology, we cannot understand the information contained within a genome until we mine out its implicated functions. Therefore, the major challenges we meet today are not those of the traditional approach but instead fall under the task of functional annotation of genomes, which includes dynamic aspects such as gene identification, gene transcription, translation, modification, and protein-protein interactions using bioinformatic tools and high-throughput methods. In addition, the genetic information implicated in a genome sequence is critical for understanding the relationship between the genome and its expressed traits. Some diseases are reported as being caused by genetic disorders, such as changes or mutations of DNA, which can be inherited from parents; for example, Edward syndrome is caused by the anomalous presence of three copies of chromosome 18 in each cell. In contrast to such genetic causes, epigenetic ones are thought as changes of gene expression without changes of DNA sequence, and epigenetic alternation may be caused by environment or other postnatal factors. Most diseases such as colorectal cancer are caused by both accumulated alternations of genetic and epigenetic factors, so faster and more accurate methods are urgently needed for next-generation sequence data analysis. In this special issue, we would focus on functional “-omics” and bioinformatics.

The special issue will provide a platform to integrate the most recent development and ideas in the field. We call for original research articles and reviews on the following topics. Potential topics include, but not limited to:

  • Translational bioinformatics, focused more on using bioinformatics methods to analyze “-omics” data
  • Functional study of specific molecular and pathway analysis
  • Computational systems biology
  • Bioinformatics algorithm and tool development: any new tools, methods, and their evaluation for “-omics” data analysis
  • Medical and health informatics by using “-omics” data
  • Integrative data analysis
  • Genome annotation and comparative genomics
  • Traditional bioinformatics

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/bioinformatics/ggb/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 184824
  • - Editorial

Functional Genomics, Genetics, and Bioinformatics

Youping Deng | Hongwei Wang | ... | Shiwei Duan
  • Special Issue
  • - Volume 2015
  • - Article ID 613910
  • - Research Article

Evolutionary Pattern and Regulation Analysis to Support Why Diversity Functions Existed within PPAR Gene Family Members

Tianyu Zhou | Xiping Yan | ... | Liang Li
  • Special Issue
  • - Volume 2015
  • - Article ID 207347
  • - Research Article

The Expression and Distributions of ANP32A in the Developing Brain

Shanshan Wang | Yunliang Wang | ... | Dajin Zhang
  • Special Issue
  • - Volume 2015
  • - Article ID 689745
  • - Research Article

Shaped Singular Spectrum Analysis for Quantifying Gene Expression, with Application to the Early Drosophila Embryo

Alex Shlemov | Nina Golyandina | ... | Alexander Spirov
  • Special Issue
  • - Volume 2015
  • - Article ID 308475
  • - Research Article

Effect of Celastrol on Growth Inhibition of Prostate Cancer Cells through the Regulation of hERG Channel In Vitro

Nan Ji | Jinjun Li | ... | Youping Deng
  • Special Issue
  • - Volume 2015
  • - Article ID 898592
  • - Research Article

The Plant Growth-Promoting Bacteria Azospirillum amazonense: Genomic Versatility and Phytohormone Pathway

Ricardo Cecagno | Tiago Ebert Fritsch | Irene Silveira Schrank
  • Special Issue
  • - Volume 2015
  • - Article ID 124721
  • - Research Article

Protecting Intestinal Epithelial Cell Number 6 against Fission Neutron Irradiation through NF-κB Signaling Pathway

Gong-Min Chang | Ya-Bing Gao | ... | Rui-Yun Peng
  • Special Issue
  • - Volume 2014
  • - Article ID 909657
  • - Research Article

Human Umbilical Cord Mesenchymal Stem Cells Infected with Adenovirus Expressing HGF Promote Regeneration of Damaged Neuron Cells in a Parkinson’s Disease Model

Xin-Shan Liu | Jin-Feng Li | ... | Yun-Liang Wang
  • Special Issue
  • - Volume 2014
  • - Article ID 106252
  • - Research Article

Relationship between CCR and NT-proBNP in Chinese HF Patients, and Their Correlations with Severity of HF

Zhigang Lu | Bo Wang | ... | Meng Wei
  • Special Issue
  • - Volume 2014
  • - Article ID 708364
  • - Research Article

Characterization of Putative cis-Regulatory Elements in Genes Preferentially Expressed in Arabidopsis Male Meiocytes

Junhua Li | Jinhong Yuan | Mingjun Li
BioMed Research International
 Journal metrics
Acceptance rate30%
Submission to final decision70 days
Acceptance to publication36 days
CiteScore2.410
Impact Factor2.197
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