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Ischemia-Reperfusion Injury and Anesthesia

Call for Papers

After the ischemic period reentry of the blood to tissue causes massive amounts of oxygen free radicals release. Oxygen free radicals trigger some enzymatic reactions; peroxidation of polyunsaturated fatty acids or plasma lipoproteins leads to oxidative destructions of cell membranes and the productions of toxic reactive metabolites and cell injury involving DNA, proteins, and lipids. All of these events are named ischemia-reperfusion injury (IRI). IRI is occurred on different models. On pump cardiac surgery, tourniquet application for extremity surgery, thromboembolic events and revascularization, severe hypotension, and currently very actual, organ transplantation may cause IRI. Various markers are used to detect IRI. Malonyldialdehyde (MDA), ischaemia modified albumin (IMA), catalase, peroxidase, total oxidant capacity, and total antioxidant capacity are often used for this purpose.

IRI may cause cardiopulmonary complication such as tachyarrhythmia and hypoxia. Thus a lot of studies are conducted to prevent IRI. Some of these are related anesthesia method such as regional anesthesia, inhaler general anesthesia, or total intravenous anesthesia. Some of these are related drugs such as vitamin E, propofol, n-acetyl cysteine, and dexmedetomidine.

We invite authors to submit original research and review articles that seek to define the interaction between ischemia-reperfusion injury and anesthesia. We are interested in articles that explore aspects of the effect of anesthesia on ischemia-reperfusion injury in humans and also in animal models. Potential topics include, but are not limited to:

  • The model of IRI
  • The preventive method of IRI
  • The drugs that decrease the IRI
  • The markers of IRI
  • Duration of ischemia and reperfusion
  • Inhalation anesthetic agents and IRI
  • Intravenous anesthetic drugs and IRI
  • Regional anesthesia and IRI

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:

Manuscript DueFriday, 1 November 2013
First Round of ReviewsFriday, 24 January 2014
Publication DateFriday, 21 March 2014

Lead Guest Editor

  • Ahmet Eroglu, Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey

Guest Editors

  • Engin Erturk, Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Karadeniz Technical University, 61000 Trabzon, Turkey
  • Can Ince, Department of Intensive Care Medicine, Erasmus Medical Center, Erasmus University Rotterdam, 3000 CA Rotterdam, The Netherlands
  • Martin Westphal, Fresenius Kabi AG, Else-Kröner-Straße 1, 61352 Bad Homburg, Germany